Epigenetic Regulation of Processes Related to High Level of Fibroblast Growth Factor 21 in Obese Subjects

• Published in: Genes Vol. 12; no. 2; p. 307
• Main Authors: Płatek, Teresa, Polus, Anna, Góralska, Joanna, Raźny, Urszula, Dziewońska, Agnieszka, Micek, Agnieszka, Dembińska-Kieć, Aldona, Solnica, Bogdan, Malczewska-Malec, Małgorzata
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.02.2021; MDPI
• Subjects: Adiponectin; Adipose tissue; blood serum; bone mineralization; Cytokines; Deoxyribonucleic acid; DNA; DNA methylation; DNA microarrays; Epigenetics; fibroblast growth factor receptors; Fibroblast growth factors; Gene regulation; glucose; Glucose transport; heat production; humans; Insulin; Insulin resistance; Insulin secretion; Leukocytes; Lipid metabolism; Lipids; Metabolic pathways; metabolism; microarray technology; microRNA; Mineralization; miRNA; Obesity; Serum levels; Signal transduction; Thermogenesis; transcription factors; Vascular endothelial growth factor; vascular endothelial growth factor receptors; Minneapolis Minnesota; Czech Republic; Belgium; United States > US; Germany; DNA methylation; microRNA; glucose and lipid metabolism; obesity; FGF21

We hypothesised that epigenetics may play an important role in mediating fibroblast growth factor 21 (FGF21) resistance in obesity. We aimed to evaluate DNA methylation changes and miRNA pattern in obese subjects associated with high serum FGF21 levels. The study included 136 participants with BMI 2...