Maternal hsa-miR-423-5p associated with the cognitive development of babies in pregnant women without mental disorders

MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, gro...

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Published inFrontiers in human neuroscience Vol. 18; p. 1322820
Main Authors do Amaral, Cainá Corrêa, Nedel, Fernanda, Ferrúa, Camila Perelló, Garcia, Tiago Fernandez, Corrêa, Geovanna Peter, Giorgi, Roberta, Longoni Dos Santos, Aline, de Assis, Adriano Martimbianco, de Avila Quevedo, Luciana, Ghisleni, Gabriele Cordenonzi, de Matos, Mariana Bonati, Pinheiro, Karen Amaral Tavares, Trettim, Jéssica Puchalski, Pinheiro, Ricardo Tavares
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Research Foundation 29.02.2024
Frontiers Media S.A
Subjects
Babies
Body mass index
Breastfeeding & lactation
Child development
Children & youth
Cognition
Cognitive ability
Cognitive development
Critical period
Epigenetics
Gene expression
Gestational age
Human Neuroscience
Infants
Mental disorders
Mental health
microRNA
MicroRNAs
miRNA
Non-coding RNA
Population studies
Post-transcription
Pregnancy
Regression analysis
retinoic acid
Thermal cycling
Womens health
cognitive development
microRNA
retinoic acid
babies
pregnancy
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Abstract MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth. The aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR. In total, 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43,  = 0.021) points at 3 months of age. In this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions.
AbstractList Background: MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth. Objective: was to investigate the association between maternal expression of has-miR-423-5p during the first and second trimester of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the outcome of the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR. Results: 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD±5.55). An association of maternal miRNA with infant cognitive development was found, as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43, p = 0.021) points at three months of age. Conclusion: In this contextsense, it is possible suggested that to aim to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions.
MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth. The aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR. In total, 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43,  = 0.021) points at 3 months of age. In this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions.
Background MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy–puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the “building blocks” of children’s later growth. Objective The aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies’ cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR. Results In total, 87 dyads (mother–baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants’ cognitive development increases by 2.40 (95% CI 0.37; 4.43, p  = 0.021) points at 3 months of age. Conclusion In this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions.
BackgroundMicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth.ObjectiveThe aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR.ResultsIn total, 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43, p = 0.021) points at 3 months of age.ConclusionIn this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions.
Author Corrêa, Geovanna Peter
de Matos, Mariana Bonati
de Avila Quevedo, Luciana
Giorgi, Roberta
Ghisleni, Gabriele Cordenonzi
Pinheiro, Karen Amaral Tavares
Trettim, Jéssica Puchalski
Pinheiro, Ricardo Tavares
Ferrúa, Camila Perelló
de Assis, Adriano Martimbianco
do Amaral, Cainá Corrêa
Nedel, Fernanda
Garcia, Tiago Fernandez
Longoni Dos Santos, Aline
AuthorAffiliation 1 Post-Graduate Program in Health and Behavior, Catholic University of Pelotas , Pelotas , Brazil
3 Department of Ophthalmology, Faculty of Medicine, Federal University of Rio Grande , Rio Grande , Brazil
2 Anatomy Department, Federal University of Pelotas , Pelotas , Brazil
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Keywords cognitive development
microRNA
retinoic acid
babies
pregnancy
Language English
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Guadalupe García, Instituto Nacional de Perinatología (INPER), Mexico
Reviewed by: Danielle Rayêe, Albert Einstein College of Medicine, United States
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Snippet MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse...
Background MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators...
Background: MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators...
BackgroundMicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of...
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StartPage 1322820
SubjectTerms Babies
Body mass index
Breastfeeding & lactation
Child development
Children & youth
Cognition
Cognitive ability
Cognitive development
Critical period
Epigenetics
Gene expression
Gestational age
Human Neuroscience
Infants
Mental disorders
Mental health
microRNA
MicroRNAs
miRNA
Non-coding RNA
Population studies
Post-transcription
Pregnancy
Regression analysis
retinoic acid
Thermal cycling
Womens health
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Title Maternal hsa-miR-423-5p associated with the cognitive development of babies in pregnant women without mental disorders
URI https://www.ncbi.nlm.nih.gov/pubmed/38487105
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Volume 18
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