Maternal hsa-miR-423-5p associated with the cognitive development of babies in pregnant women without mental disorders
MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, gro...
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Published in | Frontiers in human neuroscience Vol. 18; p. 1322820 |
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Abstract | MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth.
The aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR.
In total, 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43,
= 0.021) points at 3 months of age.
In this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions. |
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AbstractList | Background: MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth. Objective: was to investigate the association between maternal expression of has-miR-423-5p during the first and second trimester of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the outcome of the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR. Results: 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD±5.55). An association of maternal miRNA with infant cognitive development was found, as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43, p = 0.021) points at three months of age. Conclusion: In this contextsense, it is possible suggested that to aim to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions. MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth. The aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR. In total, 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43, = 0.021) points at 3 months of age. In this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions. Background MicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy–puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the “building blocks” of children’s later growth. Objective The aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies’ cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR. Results In total, 87 dyads (mother–baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants’ cognitive development increases by 2.40 (95% CI 0.37; 4.43, p = 0.021) points at 3 months of age. Conclusion In this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions. BackgroundMicroRNAs (miRNAs) are small non-coding RNAs capable of regulating gene expression post-transcriptionally. MiRNAs are recognized as key regulators of diverse biological and developmental processes. During the pregnancy-puerperal cycle, numerous changes occur in the female body for the formation, growth, and development of the baby. After birth, there is a critical period in child development, as rapid gains in the physical, cognitive, and socio-emotional domains constitute the "building blocks" of children's later growth.ObjectiveThe aim of this study was to investigate the association between maternal expression of hsa-miR-423-5p during the first and second trimesters of pregnancy and neurocognitive development at 90 days of life in infants. Methods: This is a longitudinal study included in a population-based cohort study, carried out in a city in southern Brazil. The Bayley III was used to assess the babies' cognitive development. Blood samples from mothers were obtained for RNA extraction from serum and analysis of miRNA expression by qRT-PCR.ResultsIn total, 87 dyads (mother-baby) were included. The average gestational age was 15.86 weeks (SD ± 5.55). An association of maternal miRNA with infant cognitive development was found; as maternal miR-423-5p increases, infants' cognitive development increases by 2.40 (95% CI 0.37; 4.43, p = 0.021) points at 3 months of age.ConclusionIn this context, it is suggested to use this miRNA as a biomarker of child neurocognitive development detectable in the prenatal period, thus allowing the planning of early interventions. |
Author | Corrêa, Geovanna Peter de Matos, Mariana Bonati de Avila Quevedo, Luciana Giorgi, Roberta Ghisleni, Gabriele Cordenonzi Pinheiro, Karen Amaral Tavares Trettim, Jéssica Puchalski Pinheiro, Ricardo Tavares Ferrúa, Camila Perelló de Assis, Adriano Martimbianco do Amaral, Cainá Corrêa Nedel, Fernanda Garcia, Tiago Fernandez Longoni Dos Santos, Aline |
AuthorAffiliation | 1 Post-Graduate Program in Health and Behavior, Catholic University of Pelotas , Pelotas , Brazil 3 Department of Ophthalmology, Faculty of Medicine, Federal University of Rio Grande , Rio Grande , Brazil 2 Anatomy Department, Federal University of Pelotas , Pelotas , Brazil |
AuthorAffiliation_xml | – name: 3 Department of Ophthalmology, Faculty of Medicine, Federal University of Rio Grande , Rio Grande , Brazil – name: 1 Post-Graduate Program in Health and Behavior, Catholic University of Pelotas , Pelotas , Brazil – name: 2 Anatomy Department, Federal University of Pelotas , Pelotas , Brazil |
Author_xml | – sequence: 1 givenname: Cainá Corrêa surname: do Amaral fullname: do Amaral, Cainá Corrêa organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 2 givenname: Fernanda surname: Nedel fullname: Nedel, Fernanda organization: Anatomy Department, Federal University of Pelotas, Pelotas, Brazil – sequence: 3 givenname: Camila Perelló surname: Ferrúa fullname: Ferrúa, Camila Perelló organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 4 givenname: Tiago Fernandez surname: Garcia fullname: Garcia, Tiago Fernandez organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 5 givenname: Geovanna Peter surname: Corrêa fullname: Corrêa, Geovanna Peter organization: Anatomy Department, Federal University of Pelotas, Pelotas, Brazil – sequence: 6 givenname: Roberta surname: Giorgi fullname: Giorgi, Roberta organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 7 givenname: Aline surname: Longoni Dos Santos fullname: Longoni Dos Santos, Aline organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 8 givenname: Adriano Martimbianco surname: de Assis fullname: de Assis, Adriano Martimbianco organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 9 givenname: Luciana surname: de Avila Quevedo fullname: de Avila Quevedo, Luciana organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 10 givenname: Gabriele Cordenonzi surname: Ghisleni fullname: Ghisleni, Gabriele Cordenonzi organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 11 givenname: Mariana Bonati surname: de Matos fullname: de Matos, Mariana Bonati organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 12 givenname: Karen Amaral Tavares surname: Pinheiro fullname: Pinheiro, Karen Amaral Tavares organization: Department of Ophthalmology, Faculty of Medicine, Federal University of Rio Grande, Rio Grande, Brazil – sequence: 13 givenname: Jéssica Puchalski surname: Trettim fullname: Trettim, Jéssica Puchalski organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil – sequence: 14 givenname: Ricardo Tavares surname: Pinheiro fullname: Pinheiro, Ricardo Tavares organization: Post-Graduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil |
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Keywords | cognitive development microRNA retinoic acid babies pregnancy |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Guadalupe García, Instituto Nacional de Perinatología (INPER), Mexico Reviewed by: Danielle Rayêe, Albert Einstein College of Medicine, United States Edited by: Lutz Jäncke, University of Zurich, Switzerland |
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SubjectTerms | Babies Body mass index Breastfeeding & lactation Child development Children & youth Cognition Cognitive ability Cognitive development Critical period Epigenetics Gene expression Gestational age Human Neuroscience Infants Mental disorders Mental health microRNA MicroRNAs miRNA Non-coding RNA Population studies Post-transcription Pregnancy Regression analysis retinoic acid Thermal cycling Womens health |
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Title | Maternal hsa-miR-423-5p associated with the cognitive development of babies in pregnant women without mental disorders |
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