Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

• Published in: eLife Vol. 12
• Main Authors: Kidwell, Chelsea U, Casalini, Joseph R, Pradeep, Soorya, Scherer, Sandra D, Greiner, Daniel, Bayik, Defne, Watson, Dionysios C, Olson, Gregory S, Lathia, Justin D, Johnson, Jarrod S, Rutter, Jared, Welm, Alana L, Zangle, Thomas A, Roh-Johnson, Minna
• Format: Journal Article
• Language: English
• Published: England eLife Sciences Publications, Ltd 06.03.2023; eLife Sciences Publications Ltd
• Subjects: cancer; Cancer Biology; Cell Biology; Cell Proliferation; cell-cell communication; Humans; macrophages; Mitochondria - metabolism; mitochondrial transfer; Neoplasms - pathology; reactive oxygen species; Reactive Oxygen Species - metabolism; Signal Transduction; mouse; macrophages; cell biology; cell proliferation; reactive oxygen species; mitochondrial transfer; cancer; cancer biology; cell-cell communication; human

Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from one cell to another, can affect cellular and tissue homeostasis. Most of what we know about mitochondrial transfer stems from bulk cell studies and have led to the paradigm that functional transferred mitoch...