Guillain-Barré Syndrome Associated with Minimal Change Glomerulopathy and Tubular Dysfunction – Related to Acetone-Based Organic Solvent?

• Published in: American journal of nephrology Vol. 22; no. 5-6; pp. 560 - 565
• Main Authors: Chen, Jiann-Keh, Wu, Mai-Szu, Yang, Chih-Wei, Huang, Jeng-Yi, Hsu, Po-Yaur, Lin, Chun-Liang, Huang, Chiu-Ching
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Karger 01.09.2002; S. Karger AG
• Subjects: Acetone - poisoning; Biological and medical sciences; Case Report; Female; Glomerulonephritis; Guillain-Barre Syndrome - chemically induced; Guillain-Barre Syndrome - complications; Humans; Medical sciences; Middle Aged; Nephritis, Interstitial - chemically induced; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Nephrosis, Lipoid - chemically induced; Nephrosis, Lipoid - complications; Occupational Exposure; Solvents - poisoning; Switzerland, Basel; Renal tubular dysfunction; Guillain-Barré syndrome; Minimal change nephrotic syndrome; Acetone; Human; Glomerulonephritis; Kidney disease; Nervous system diseases; Urinary system disease; Tubulopathy; Kidney; Inflammatory disease; Case study; Pathology; Organic solvent; Association; Biopsy; Adult; Female; Poisoning; Peripheral nerve disease; Diagnosis; Guillain Barré syndrome
• DOI: 10.1159/000065268
• ISSN: 0250-8095

A 55-year-old woman presented with Guillain-Barré syndrome, nephrotic syndrome and multiple tubular dysfunction under occupational exposure to an organic solvent, which contained acetone as the principal solvent. In this case, the onset of the nephrotic syndrome and tubular dysfunction coincided with the development of the neurological manifestation. Renal biopsy demonstrated minimal change glomerulopathy with moderate tubulointerstitial nephritis. Several clearance tests that evaluated tubular transport functions revealed multiple tubular defects (including the Na + -K + -Cl – cotransporter of thick ascending limb and distal proton pump). The simultaneous occurrence of Guillain-Barré and nephrotic syndrome has previously been reported. However, both minimal glomerulopathy with multiple tubular dysfunction and progressive peripheral neuropathy under occupational exposure to an organic solvent remain unreported. Herein, we presented a rare association of minimal change nephrotic syndrome, tubular dysfunction with Guillain-Barré syndrome under the risk of exposure to an acetone-based cleansing solution; the case raises our concerns about possible chronic nephrotoxic or neurotoxic effects of common chemical organic solvents.