Mitochondrial DNA and Epigenetics: Investigating Interactions with the One-Carbon Metabolism in Obesity

• Published in: Oxidative medicine and cellular longevity Vol. 2022; no. 1; p. 9171684
• Main Authors: Bordoni, Laura, Petracci, Irene, Mlodzik-Czyzewska, Monika, Malinowska, Anna M., Szwengiel, Artur, Sadowski, Marcin, Gabbianelli, Rosita, Chmurzynska, Agata
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2022; John Wiley & Sons, Inc
• Subjects: Adult; Biomarkers; Biomarkers - blood; Body Composition; Body Mass Index; Carbon - metabolism; Case-Control Studies; Cohort Studies; DNA Copy Number Variations; DNA Methylation; DNA, Mitochondrial - blood; DNA, Mitochondrial - genetics; Epigenesis, Genetic; Epigenetics; Female; Glutathione; Glutathione - blood; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Methylenetetrahydrofolate Reductase (NADPH2) - metabolism; Mitochondria - metabolism; Mitochondrial DNA; Obesity; Obesity - blood; Obesity - epidemiology; Obesity - genetics; Poland - epidemiology; Signal Transduction - genetics; Young Adult; Poland; United States > US

Mitochondrial DNA copy number (mtDNAcn) has been proposed for use as a surrogate biomarker of mitochondrial health, and evidence suggests that mtDNA might be methylated. Intermediates of the one-carbon cycle (1CC), which is duplicated in the cytoplasm and mitochondria, have a major role in modulatin...