Metabolic pathways of eicosanoids—derivatives of arachidonic acid and their significance in skin

• Published in: Cellular & molecular biology letters Vol. 30; no. 1; pp. 7 - 35
• Main Authors: Biernacki, Michał, Skrzydlewska, Elżbieta
• Format: Journal Article
• Language: English
• Published: England BioMed Central 17.01.2025; BMC
• Subjects: Animals; Arachidonic acid; Arachidonic Acid - metabolism; Atopic dermatitis; Biosynthesis; Cell membranes; Cells; Cholesterol; Cyclooxygenases; Cytochrome P450; Dermatitis; Eicosanoids; Eicosanoids - metabolism; Environmental factors; Fatty acids; Fibroblasts; Homeostasis; Humans; Lipid metabolism; Lipid peroxidation; Lipids; Lipoxygenases; Membranes; Metabolic disorders; Metabolic Networks and Pathways; Metabolic pathways; Metabolism; Metabolites; Pathogens; Phospholipases; Phospholipids; Phospholipids metabolism; Polyunsaturated fatty acids; Proteins; Psoriasis; Review; Skin; Skin - metabolism; Skin diseases; Solar radiation; Structure-function relationships; Ultraviolet radiation; Lipoxygenases; Prostaglandins; Leukotrienes; Cytochrome P450; Eicosanoids; Cyclooxygenases; Phospholipases; Phospholipids metabolism; Fatty acids

The skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, chemicals, and pathogens). The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell membrane, the important structural and metabolic el...