Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans

• Published in: Biogerontology (Dordrecht) Vol. 14; no. 2; pp. 177 - 186
• Main Authors: Montesanto, Alberto, Crocco, Paolina, Tallaro, Federica, Pisani, Francesca, Mazzei, Bruno, Mari, Vincenzo, Corsonello, Andrea, Lattanzio, Fabrizia, Passarino, Giuseppe, Rose, Giuseppina
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.04.2013; Springer Nature B.V
• Subjects: Activities of Daily Living - psychology; Adult; Age; Aged; Aged, 80 and over; Aging; Aging - genetics; Aging - psychology; Biomedical and Life Sciences; Case-Control Studies; Cell Biology; Cognition; Depression - genetics; Depression - psychology; Developmental Biology; Enzymes; Female; Geriatric Assessment; Geriatrics/Gerontology; Humans; Life Sciences; Longevity - genetics; Male; Middle Aged; Nitric oxide; Nitric Oxide Synthase Type I - genetics; Nitric Oxide Synthase Type II - genetics; Nitric Oxide Synthase Type III - genetics; Older people; Phenotype; Polymorphism, Single Nucleotide - genetics; Quality of life; Research Article; Signal transduction; Italy; Aging; NOS; Longevity; Polymorphisms; Nitric oxide

Nitric oxide (NO) triggers multiple signal transduction pathways and contributes to the control of numerous cellular functions. Previous studies have shown in model organisms that the alteration of NO production has important effects on aging and lifespan. We studied in a large sample (763 subjects,...