Altered Small-World Functional Network Topology in Patients with Optic Neuritis: A Resting-State fMRI Study

• Published in: Disease markers Vol. 2021; pp. 1 - 9
• Main Authors: Song, Ke, Li, Juan, Zhu, Yuanqiang, Ren, Fang, Cao, Lingcan, Huang, Zi-Gang
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc
• Subjects: Alzheimer's disease; Amygdala; Brain; Brain mapping; Case-Control Studies; Cerebellum; Clustering; Cognitive ability; Connectome - methods; Correlation coefficient; Correlation coefficients; Efficiency; Female; Females; Frontal gyrus; Functional magnetic resonance imaging; Globus pallidus; Graph theory; Gyrus Cinguli - diagnostic imaging; Humans; Insular Cortex - diagnostic imaging; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Males; Mathematical analysis; Nervous system; Network topologies; Neural networks; Neuritis; Neuroimaging; Operculum; Optic neuritis; Optic Neuritis - diagnostic imaging; Parameters; Pathogenesis; Prefrontal Cortex - diagnostic imaging; Rest; Software; Sparsity; Statistical analysis; Superior temporal gyrus; Temporal gyrus; Time series; Topology
• ISSN: 0278-0240; 1875-8630; 1875-8630
• DOI: 10.1155/2021/9948751

Aim. This study investigated changes in small-world topology and brain functional connectivity in patients with optic neuritis (ON) by resting-state functional magnetic resonance imaging (rs-fMRI) and based on graph theory. Methods. A total of 21 patients with ON (8 males and 13 females) and 21 matc...