A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir cream (5%) in the treatment of oral hairy leukoplakia

• Published in: Oral surgery, oral medicine, oral pathology, oral radiology and endodontics Vol. 103; no. 1; pp. 64 - 71
• Main Authors: Moura, Mariela Dutra Gontijo, DDS, MS, Guimarães, Tatiane Roberta Morais, Fonseca, Linaena Méricy Silva, DDS, PhD, de Almeida Pordeus, Isabela, DDS, PhD, Mesquita, Ricardo Alves, DDS, PhD
• Format: Journal Article
• Language: English
• Published: St. Louis, MO Mosby, Inc 2007; Elsevier
• Subjects: Acyclovir - administration & dosage; Administration, Topical; Adult; Antiviral Agents - administration & dosage; Biological and medical sciences; Dentistry; Drug Therapy, Combination; HIV Infections - complications; Humans; Keratolytic Agents - administration & dosage; Leukoplakia, Hairy - drug therapy; Medical sciences; Middle Aged; Otorhinolaryngology. Stomatology; Podophyllin - administration & dosage; Surgery; Acyclic nucleoside; Purine nucleoside; Cream; Oral administration; Hairy leukoplakia; Local administration; Treatment; Efficiency; Aciclovir; Nucleoside analog; Antiviral; Clinical trial; Resins; Comparative study; Topical administration
• ISSN: 1079-2104; 1528-395X
• DOI: 10.1016/j.tripleo.2006.02.016

Objective The objective of this study was to assess the efficiency of topical applications of podophyllin resin (25%) (P) versus podophyllin resin (25%) together with acyclovir cream (5%) (PA) in the treatment of oral hairy leukoplakia (OHL) in accordance with the following criteria: (1) number of applications necessary for the total clinical resolution of OHL; (2) correlation between the decrease of lesion size and the number of applications; (3) total clinical resolution of OHL; and (4) clinical reevaluation 12 months after the end of treatment. Study design Forty-six OHLs were treated with P (P group) or with PA (PA group). Applications were performed weekly. Student t , Fisher exact, and Pearson correlation tests were used for statistical analysis. Results All 24 lesions from the PA group presented total clinical resolution while 4 lesions from the P group did not. The P group required up to 25 applications performed weekly while the PA group required up to 18. Observed was a negative significant association between the size of the lesions and the number of applications performed weekly in the PA group. Conclusions The present study demonstrated the following: (1) P and PA topical treatments presented a similar average number of applications performed weekly; (2) both groups showed the same clinical response at 12 months post-therapy; and (3) PA presented a 100% clinical resolution and a continuous decrease in OHL size over the course of weekly applications.