Suppressive Effect of Tetrahydrocurcumin on Pseudomonas aeruginosa Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells

Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of c...

Full description

Saved in:
Bibliographic Details
Published inOxidative medicine and cellular longevity Vol. 2022; no. 1; p. 4978556
Main Authors Lin, Hui-Wen, Chen, Tzu-Chun, Yeh, Jui-Hsuan, Tsou, Shang-Chun, Wang, Inga, Shen, Ting-Jing, Chuang, Chen-Ju, Chang, Yuan-Yen
Format Journal Article
LanguageEnglish
Published United States Hindawi 2022
John Wiley & Sons, Inc
Subjects
Alzheimer's disease
Animals
Antibodies
Antioxidants
Curcumin - analogs & derivatives
Curcumin - metabolism
Curcumin - pharmacology
Cytokines
Cytotoxicity
Heme Oxygenase-1 - metabolism
Inflammation
Inflammation - chemically induced
Inflammation - drug therapy
Inflammation - metabolism
Janus Kinase 1
Kinases
Lipopolysaccharides - pharmacology
Mice
Microglia - metabolism
NF-E2-Related Factor 2 - metabolism
Nitric Oxide - metabolism
Proteins
Pseudomonas aeruginosa
Vantaa Finland
United States > US
Finland
Online AccessGet full text

Cover

Abstract Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat Pseudomonas aeruginosa (P.a.) lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced P.a. LPS–induced mortality and the production of inflammatory mediators IL-6, TNF-α, MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNFκB cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in P.a. LPS–stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in P.a. LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF-κB activation and inducing Nrf2-mediated HO-1 expression.
AbstractList Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat Pseudomonas aeruginosa ( P.a. ) lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced P.a. LPS–induced mortality and the production of inflammatory mediators IL-6, TNF- α , MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNF κ B cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in P.a. LPS–stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in P.a. LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF- κ B activation and inducing Nrf2-mediated HO-1 expression.
Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat ( ) lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced LPS-induced mortality and the production of inflammatory mediators IL-6, TNF- , MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNF B cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in LPS-stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF- B activation and inducing Nrf2-mediated HO-1 expression.
Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat Pseudomonas aeruginosa (P.a.) lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced P.a. LPS-induced mortality and the production of inflammatory mediators IL-6, TNF-α, MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNFκB cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in P.a. LPS-stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in P.a. LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF-κB activation and inducing Nrf2-mediated HO-1 expression.Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat Pseudomonas aeruginosa (P.a.) lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced P.a. LPS-induced mortality and the production of inflammatory mediators IL-6, TNF-α, MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNFκB cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in P.a. LPS-stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in P.a. LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF-κB activation and inducing Nrf2-mediated HO-1 expression.
Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti‐inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat Pseudomonas aeruginosa ( P.a. ) lipopolysaccharide‐ (LPS‐) stimulated BV2 microglial cells. THC reduced P.a. LPS–induced mortality and the production of inflammatory mediators IL‐6, TNF‐ α , MIP‐2, IP‐10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO‐1 signaling transduction which inhibits iNOS/COX‐2/pNF κ B cascades. Additionally, the presence of the HO‐1 inhibitor Snpp increased the levels of IP‐10, IL‐6, and nitrite while THC treatment reduced those inflammatory factors in P.a. LPS–stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti‐inflammatory activities in P.a. LPS‐induced inflammation in brain microglial cells by inhibiting STAT1/3‐dependent NF‐ κ B activation and inducing Nrf2‐mediated HO‐1 expression.
Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors. The present study was aimed at assessing the anti-inflammatory response of tetrahydrocurcumin (THC), the primary hydrogenated metabolite of curcumin, which was applied to treat Pseudomonas aeruginosa (P.a.) lipopolysaccharide- (LPS-) stimulated BV2 microglial cells. THC reduced P.a. LPS–induced mortality and the production of inflammatory mediators IL-6, TNF-α, MIP-2, IP-10, and nitrite. A further investigation revealed that THC decreased these inflammatory cytokines synergistically with JAK/STAT signaling inhibitors. THC also increased Nrf2/HO-1 signaling transduction which inhibits iNOS/COX-2/pNFκB cascades. Additionally, the presence of the HO-1 inhibitor Snpp increased the levels of IP-10, IL-6, and nitrite while THC treatment reduced those inflammatory factors in P.a. LPS–stimulated BV2 cells. In summary, we demonstrated that THC exhibits anti-inflammatory activities in P.a. LPS-induced inflammation in brain microglial cells by inhibiting STAT1/3-dependent NF-κB activation and inducing Nrf2-mediated HO-1 expression.
Author Chuang, Chen-Ju
Yeh, Jui-Hsuan
Chen, Tzu-Chun
Wang, Inga
Chang, Yuan-Yen
Shen, Ting-Jing
Lin, Hui-Wen
Tsou, Shang-Chun
AuthorAffiliation 7 Emergency Department, Kaohsiung Municipal United Hospital, Kaohsiung 80457, Taiwan
8 Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
2 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
4 Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
6 Department of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, Taichung 40201, Taiwan
3 Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
5 Rehabilitation Sciences & Technology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA
1 Department of Optometry, Asia University, Taichung 41354, Taiwan
AuthorAffiliation_xml – name: 1 Department of Optometry, Asia University, Taichung 41354, Taiwan
– name: 4 Department of Nutrition, Chung Shan Medical University, Taichung 40201, Taiwan
– name: 5 Rehabilitation Sciences & Technology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA
– name: 2 Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan
– name: 6 Department of Microbiology and Immunology, School of Medicine, Chung-Shan Medical University, Taichung 40201, Taiwan
– name: 8 Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
– name: 7 Emergency Department, Kaohsiung Municipal United Hospital, Kaohsiung 80457, Taiwan
– name: 3 Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
Author_xml – sequence: 1
  givenname: Hui-Wen
  surname: Lin
  fullname: Lin, Hui-Wen
  organization: Department of OptometryAsia UniversityTaichung 41354Taiwanasia.edu.tw
– sequence: 2
  givenname: Tzu-Chun
  surname: Chen
  fullname: Chen, Tzu-Chun
  organization: Institute of MedicineChung Shan Medical UniversityTaichung 40201Taiwancsmu.edu.tw
– sequence: 3
  givenname: Jui-Hsuan
  surname: Yeh
  fullname: Yeh, Jui-Hsuan
  organization: Institute of MedicineChung Shan Medical UniversityTaichung 40201Taiwancsmu.edu.tw
– sequence: 4
  givenname: Shang-Chun
  surname: Tsou
  fullname: Tsou, Shang-Chun
  organization: Department of NutritionChung Shan Medical UniversityTaichung 40201Taiwancsmu.edu.tw
– sequence: 5
  givenname: Inga
  surname: Wang
  fullname: Wang, Inga
  organization: Rehabilitation Sciences & TechnologyUniversity of Wisconsin-MilwaukeeMilwaukeeWIUSAuwm.edu
– sequence: 6
  givenname: Ting-Jing
  orcidid: 0000-0002-1714-0048
  surname: Shen
  fullname: Shen, Ting-Jing
  organization: Department of Microbiology and ImmunologySchool of MedicineChung-Shan Medical UniversityTaichung 40201Taiwancsmu.edu.tw
– sequence: 7
  givenname: Chen-Ju
  orcidid: 0000-0003-1254-7487
  surname: Chuang
  fullname: Chuang, Chen-Ju
  organization: Emergency DepartmentKaohsiung Municipal United HospitalKaohsiung 80457Taiwankmuh.gov.tw
– sequence: 8
  givenname: Yuan-Yen
  orcidid: 0000-0001-6395-4280
  surname: Chang
  fullname: Chang, Yuan-Yen
  organization: Department of Microbiology and ImmunologySchool of MedicineChung-Shan Medical UniversityTaichung 40201Taiwancsmu.edu.tw
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35308172$$D View this record in MEDLINE/PubMed
BookMark eNp9kl1v0zAUhiM0xD7gjmtkiRskCLXjOB83k6pqsEJhk1auo1PnuPGU2MFONvVH7T_OpaWCSXBly37Oed_zcRodGWswil4z-pExISYJTZJJWuaFENmz6ISVaRLTskyPDndKj6NT728pzXiSshfRMRecFixPTqKHm7HvHXqv75BcKIVyIFaRJQ4Omk3trBydHDttiDXk2uNY284a8ATQjWttrAey0L3tbbvxIGUDTtcYz009SqzJ3KgWug4GHcJXG3JQM2vyZfp1crOcLgmYmnx3KplcXsWMXMPQ3MPGk6D5TUtn162Glsywbf3L6LmC1uOr_XkW_fh0sZxdxourz_PZdBHLNC2GuOAKKaYgFWWSlqCyOhN1ludFkUm5UoXIGTAQBYRXTjNELqQQHIXMeWD4WXS-y9uPqw5riSa0o616pztwm8qCrv7-Mbqp1vauKkoeOktDgnf7BM7-HNEPVae9DCWAQTv6KslSJmha8iSgb5-gt3Z0JpS3pWjwSvOtozd_OjpY-T3JAHzYAaFj3jtUB4TRarso1XZRqv2iBDx5gks9_BpTqEe3_wp6vwtqtKnhXv9f4hFIps_Q
CitedBy_id crossref_primary_10_1007_s43440_024_00680_8
crossref_primary_10_1111_cns_14085
crossref_primary_10_3390_ijms252011266
crossref_primary_10_1016_j_fbio_2024_105665
crossref_primary_10_3389_fphar_2023_1249644
crossref_primary_10_1021_acschemneuro_3c00454
crossref_primary_10_1016_j_indcrop_2023_117353
crossref_primary_10_1080_10717544_2023_2254530
crossref_primary_10_3390_nu15081989
crossref_primary_10_3390_antiox11061040
crossref_primary_10_1016_j_biopha_2024_116932
Cites_doi 10.1111/imm.12922
10.1016/j.intimp.2017.04.026
10.1042/BSR20191673
10.3389/fimmu.2021.619761
10.3389/fphar.2018.01181
10.3389/fncel.2018.00488
10.1016/j.it.2020.02.002
10.1155/2020/8856135
10.1038/s41582-019-0174-4
10.1093/carcin/bgm123
10.3892/ijmm.2018.3796
10.1186/s12974-019-1561-x
10.1016/j.pnpbp.2010.05.004
10.1007/s11064-020-03197-7
10.1002/glia.20198
10.3389/fphar.2018.00911
10.3390/toxins13120898
10.1016/j.biocel.2008.06.010
10.3390/cells9071717
10.1186/1742-2094-7-2
10.3390/foods6100092
10.4236/oji.2019.91001
10.1097/WNR.0b013e328341e141
10.1093/jn/131.8.2090
10.1038/srep24493
10.3389/fncel.2018.00400
10.1016/j.biopha.2021.111651
10.1016/j.biopha.2016.05.037
10.1016/j.freeradbiomed.2016.03.019
10.1124/jpet.116.237503
10.3390/toxins2010128
10.1016/j.ijsu.2013.10.007
10.2147/JIR.S255309
10.3390/molecules20010185
ContentType Journal Article
Copyright Copyright © 2022 Hui-Wen Lin et al.
Copyright © 2022 Hui-Wen Lin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
Copyright © 2022 Hui-Wen Lin et al. 2022
Copyright_xml – notice: Copyright © 2022 Hui-Wen Lin et al.
– notice: Copyright © 2022 Hui-Wen Lin et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0
– notice: Copyright © 2022 Hui-Wen Lin et al. 2022
DBID RHU
RHW
RHX
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7X7
7XB
88E
8FI
8FJ
8FK
8G5
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
K9.
M0S
M1P
M2O
MBDVC
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQQKQ
PQUKI
Q9U
7X8
5PM
DOI 10.1155/2022/4978556
DatabaseName Hindawi Publishing Complete
Hindawi Publishing Subscription Journals
Hindawi Publishing Open Access
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
ProQuest Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest Central
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni)
Medical Database
Research Library
Research Library (Corporate)
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
Research Library Prep
ProQuest Central Student
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Health & Medical Research Collection
ProQuest Research Library
ProQuest Central (New)
ProQuest Medical Library (Alumni)
ProQuest Central Basic
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Hospital Collection (Alumni)
ProQuest Health & Medical Complete
ProQuest Medical Library
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
MEDLINE
MEDLINE - Academic
CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: RHX
  name: Hindawi Publishing Open Access
  url: http://www.hindawi.com/journals/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1942-0994
Editor Crispi, Stefania
Editor_xml – sequence: 1
  givenname: Stefania
  surname: Crispi
  fullname: Crispi, Stefania
ExternalDocumentID PMC8933080
35308172
10_1155_2022_4978556
Genre Journal Article
GeographicLocations Vantaa Finland
United States--US
Finland
GeographicLocations_xml – name: Finland
– name: Vantaa Finland
– name: United States--US
GrantInformation_xml – fundername: Ministry of Science and Technology, Taiwan
  grantid: MOST109-2320-B-040-019-MY3; MOST106-2320-B-040-023-MY3
– fundername: Chung Shan Medical University
  grantid: NCHU-CSMU-10708; NCHU-CSMU-10613
GroupedDBID ---
3V.
4.4
53G
5VS
7X7
88E
8FI
8FJ
8G5
AAFWJ
AAJEY
ABUWG
ADBBV
ADRAZ
AENEX
AFKRA
AHMBA
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BAWUL
BCNDV
BENPR
BPHCQ
BVXVI
CCPQU
DIK
DWQXO
E3Z
EBD
EBS
EMOBN
F5P
FYUFA
GNUQQ
GROUPED_DOAJ
GUQSH
HMCUK
HYE
IAO
IEA
IHR
INH
INR
ITC
KQ8
M1P
M2O
M48
M~E
O5R
O5S
OK1
PIMPY
PQQKQ
PROAC
PSQYO
RHU
RHW
RHX
RNS
RPM
SV3
TR2
UKHRP
0R~
24P
AAMMB
AAYXX
ACCMX
AEFGJ
AGXDD
AIDQK
AIDYY
ALIPV
CITATION
EJD
H13
IPNFZ
PGMZT
PHGZM
PHGZT
RIG
CGR
CUY
CVF
ECM
EIF
NPM
7XB
8FK
K9.
MBDVC
PJZUB
PKEHL
PPXIY
PQEST
PQUKI
Q9U
7X8
5PM
ID FETCH-LOGICAL-c448t-83fe0e4acf01c09af6d65d677886ccbf8571a1a58a5d6306ee35c553e5c738863
IEDL.DBID M48
ISSN 1942-0900
1942-0994
IngestDate Thu Aug 21 14:05:39 EDT 2025
Fri Jul 11 02:52:56 EDT 2025
Fri Jul 25 21:03:55 EDT 2025
Wed Feb 19 02:26:28 EST 2025
Thu Apr 24 22:58:21 EDT 2025
Thu Jul 03 08:34:23 EDT 2025
Sun Jun 02 18:49:43 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2022 Hui-Wen Lin et al.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c448t-83fe0e4acf01c09af6d65d677886ccbf8571a1a58a5d6306ee35c553e5c738863
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Academic Editor: Stefania Crispi
ORCID 0000-0002-1714-0048
0000-0003-1254-7487
0000-0001-6395-4280
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1155/2022/4978556
PMID 35308172
PQID 2640857076
PQPubID 2037493
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_8933080
proquest_miscellaneous_2641504932
proquest_journals_2640857076
pubmed_primary_35308172
crossref_primary_10_1155_2022_4978556
crossref_citationtrail_10_1155_2022_4978556
hindawi_primary_10_1155_2022_4978556
PublicationCentury 2000
PublicationDate 2022-00-00
PublicationDateYYYYMMDD 2022-01-01
PublicationDate_xml – year: 2022
  text: 2022-00-00
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: New York
PublicationTitle Oxidative medicine and cellular longevity
PublicationTitleAlternate Oxid Med Cell Longev
PublicationYear 2022
Publisher Hindawi
John Wiley & Sons, Inc
Publisher_xml – name: Hindawi
– name: John Wiley & Sons, Inc
References e_1_2_10_22_2
e_1_2_10_23_2
e_1_2_10_20_2
e_1_2_10_21_2
e_1_2_10_19_2
e_1_2_10_1_2
e_1_2_10_3_2
e_1_2_10_17_2
e_1_2_10_2_2
e_1_2_10_18_2
e_1_2_10_5_2
e_1_2_10_15_2
e_1_2_10_4_2
e_1_2_10_16_2
e_1_2_10_7_2
e_1_2_10_13_2
e_1_2_10_6_2
e_1_2_10_14_2
e_1_2_10_9_2
e_1_2_10_11_2
e_1_2_10_34_2
e_1_2_10_8_2
e_1_2_10_12_2
e_1_2_10_33_2
e_1_2_10_32_2
e_1_2_10_10_2
e_1_2_10_31_2
e_1_2_10_30_2
e_1_2_10_28_2
e_1_2_10_29_2
e_1_2_10_26_2
e_1_2_10_27_2
e_1_2_10_24_2
e_1_2_10_25_2
References_xml – ident: e_1_2_10_5_2
  doi: 10.1111/imm.12922
– ident: e_1_2_10_17_2
  doi: 10.1016/j.intimp.2017.04.026
– ident: e_1_2_10_22_2
  doi: 10.1042/BSR20191673
– ident: e_1_2_10_15_2
  doi: 10.3389/fimmu.2021.619761
– ident: e_1_2_10_13_2
  doi: 10.3389/fphar.2018.01181
– ident: e_1_2_10_6_2
  doi: 10.3389/fncel.2018.00488
– ident: e_1_2_10_2_2
  doi: 10.1016/j.it.2020.02.002
– ident: e_1_2_10_14_2
  doi: 10.1155/2020/8856135
– ident: e_1_2_10_3_2
  doi: 10.1038/s41582-019-0174-4
– ident: e_1_2_10_26_2
  doi: 10.1093/carcin/bgm123
– ident: e_1_2_10_18_2
  doi: 10.3892/ijmm.2018.3796
– ident: e_1_2_10_19_2
  doi: 10.1186/s12974-019-1561-x
– ident: e_1_2_10_33_2
  doi: 10.1016/j.pnpbp.2010.05.004
– ident: e_1_2_10_32_2
  doi: 10.1007/s11064-020-03197-7
– ident: e_1_2_10_30_2
  doi: 10.1002/glia.20198
– ident: e_1_2_10_21_2
  doi: 10.3389/fphar.2018.00911
– ident: e_1_2_10_34_2
  doi: 10.3390/toxins13120898
– ident: e_1_2_10_24_2
  doi: 10.1016/j.biocel.2008.06.010
– ident: e_1_2_10_4_2
  doi: 10.3390/cells9071717
– ident: e_1_2_10_31_2
  doi: 10.1186/1742-2094-7-2
– ident: e_1_2_10_23_2
  doi: 10.3390/foods6100092
– ident: e_1_2_10_28_2
  doi: 10.4236/oji.2019.91001
– ident: e_1_2_10_11_2
  doi: 10.1097/WNR.0b013e328341e141
– ident: e_1_2_10_27_2
  doi: 10.1093/jn/131.8.2090
– ident: e_1_2_10_7_2
  doi: 10.1038/srep24493
– ident: e_1_2_10_8_2
  doi: 10.3389/fncel.2018.00400
– ident: e_1_2_10_12_2
  doi: 10.1016/j.biopha.2021.111651
– ident: e_1_2_10_25_2
  doi: 10.1016/j.biopha.2016.05.037
– ident: e_1_2_10_16_2
  doi: 10.1016/j.freeradbiomed.2016.03.019
– ident: e_1_2_10_29_2
  doi: 10.1124/jpet.116.237503
– ident: e_1_2_10_9_2
  doi: 10.3390/toxins2010128
– ident: e_1_2_10_20_2
  doi: 10.1016/j.ijsu.2013.10.007
– ident: e_1_2_10_1_2
  doi: 10.2147/JIR.S255309
– ident: e_1_2_10_10_2
  doi: 10.3390/molecules20010185
SSID ssj0063241
Score 2.3779008
Snippet Brain inflammation, a pathological feature of neurodegenerative disorders, exhibits elevated microglial activity and increased levels of inflammatory factors....
SourceID pubmedcentral
proquest
pubmed
crossref
hindawi
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 4978556
SubjectTerms Alzheimer's disease
Animals
Antibodies
Antioxidants
Curcumin - analogs & derivatives
Curcumin - metabolism
Curcumin - pharmacology
Cytokines
Cytotoxicity
Heme Oxygenase-1 - metabolism
Inflammation
Inflammation - chemically induced
Inflammation - drug therapy
Inflammation - metabolism
Janus Kinase 1
Kinases
Lipopolysaccharides - pharmacology
Mice
Microglia - metabolism
NF-E2-Related Factor 2 - metabolism
Nitric Oxide - metabolism
Proteins
Pseudomonas aeruginosa
SummonAdditionalLinks – databaseName: Hindawi Publishing Open Access
  dbid: RHX
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3db9MwELfYpEm8IL4pDGSk8YSi5suJ-1hNTGXAmEQn9S2ynXMbqXOmpmHKH8X_yF2SRnSA4DHxOY5y59zv7PPvGDsJJBh0jLGXhKC8WNN_0CTSs0bLONSpSaHN8r1IZlfx-UIsepKk6vctfPR2FJ6HYyqEJkRywA7QwCgony12P1wiHG_jqkkc0rKDv8tvv9N3z_McrSjkvS3-BCzv5kf-4nDOHrIHPVLk0061j9g9cI_ZUVc7snnCflA9zjaJ9TvwjoOYl5bPAZ-1anL0S_XG1NeF46XjlxXUeYkWpyquYFMvC1dWin8ubqhGQlMpQ6evihw8KuVhIOcfnUVb6c41ct3wYTS35OfTT-Nv8-mcK5fzi40Nx7OvXsAvEUzeqqbiOOYXyvNbrtG4-Sms19VTdnX2YX468_raC57BgG3ryciCD7Ey1g-MP1E2yRORE9ucTIzRVoo0UIESUuFdDDsAImGEiECYNEKZ6Bk7dKWDF4xrFU2wC37O1Mbgaz2xiApVDpZOxSoxYu93eslMT0xO9THWWRugCJGRFrNeiyP2bpC-6Qg5_iJ30qv4H2LHO_1n_eytMgSJLfF_is1vh2acd7SZohyUdSuDWDpG-DtizztzGQaKRIRIK8WWdM-QBgHi9N5vccWq5faWtMAk_Zf_9_av2H267JaEjtnhdlPDawRJW_2mnSI_AZFiDXQ
  priority: 102
  providerName: Hindawi Publishing
– databaseName: ProQuest Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1Lb9NAEF5BUSUuiPJqaEGLVE5oFb_Wdk5VVFGFAqUSqZSbtV7PJpbCOsRxK_8o_mNnbMdtEY9rduyNPbM7D89-H2NHbgwaHWMgQg-UCFLaB3UYC6PTOPDSSEfQdPmeh5PL4GwmZ13BrezaKrd7YrNRZ4WmGvkQHXcDxh6Fx6ufglij6OtqR6HxkD0i6DKy6mjWJ1yERN4kXKPAo3qEs218l5Jyfm9I7GqSqKvvuKTdBeXC1_mfIs7fGyfveKLTp-xJF0LycavzPfYA7DO225JK1s_ZLyLqbLpbr4C34MS8MHwKeK9FnaHDqta6-pFbXlh-UUKVFfhsquQK1tU8t0Wp-Jd8ReQJdak0HcvKMxDE8aEh45-sQSNqDzzytOb9bHbOz8afh9-n4ylXNuPna-MNJ9-Eyy8wyrxWdclxzq_UADhfotXzE1guyxfs8vTj9GQiOlIGoTGT24jYN-BAoLRxXO2MlAmzUGYEQxeHWqcGdeQqV8lY4a-YjwD4Ukvpg9SRjzL-S7ZjCwv7jKfKH-El-DojE4CTpiOD4aLKwNBxWSUH7MNWL4nuEMuJOGOZNJmLlAlpMem0OGDve-lVi9TxF7mjTsX_ETvc6j_plnWZ3BrhgL3rh3FB0lcWZaGoGhkMsgOMiwfsVWsu_US-9DEEi3AkumdIvQCBfd8fsfmiAf2OqfIUO6___bcO2GN6iLZGdMh2NusK3mDUtEnfNkvjBuBsF6k
  priority: 102
  providerName: ProQuest
Title Suppressive Effect of Tetrahydrocurcumin on Pseudomonas aeruginosa Lipopolysaccharide-Induced Inflammation by Suppressing JAK/STAT and Nrf2/HO-1 Pathways in Microglial Cells
URI https://dx.doi.org/10.1155/2022/4978556
https://www.ncbi.nlm.nih.gov/pubmed/35308172
https://www.proquest.com/docview/2640857076
https://www.proquest.com/docview/2641504932
https://pubmed.ncbi.nlm.nih.gov/PMC8933080
Volume 2022
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELf2oaG9ID5HYVRGGk8oNE3iOH1AqEybymClGq3Ut8hxzm2k4oymYeSP4n_knC_RaQiJlz7E51rJ3eV-55zvR8hJPwCJgdGzfAeE5UXmPSj9wFIyCjwn4pJDWeU79kcz72LO5jukYRutH2B2Z2pn-KRm69Xbn9-L9-jw70qHZ8zk707PMKUx5u-SfYxJ3HAZXHrt9wTTk7xMvQaeY3Ym7KYE_tbsQ3LPZS5GSe5sxamDpUmQb5K7YOjtaso_wtP5A3K_xpV0WBnCQ7ID-hE5qJgmi8fkl2HvLEtefwCtOhbTVNEp4H8tixijWL6W-bdE01TTSQZ5nKJ9iowKWOeLRKeZoJ-Ta8OoUGRCmrNaSQyWIf6QENOPWqFlVacgaVTQdjW9oBfDT72v0-GUCh3T8Vo5vdEXq08nCD1vRJFRXPPSVAUuVugK9BRWq-wJmZ2fTU9HVs3UYElM7zZW4CqwwRNS2X1pD4TyY5_Fpjdd4EsZqYDxvugLFgi8ikkKgMskYy4wyV2UcZ-SPZ1qeEZoJNwBTsHHyZUHdhQNFGJIEYMyZ2gF65A3jV5CWbcxN2waq7BMZxgLjULDWqEd8rqVvq7ad_xF7qRW8T_Ejhv9h42phggpS5oAjsOv2mH0UvPpRWhI81IGkbeHYLlDjipzaRdqLK5D-JYhtQKmA_j2iE6WZSfwwGxHBfbz_575ghya-6v2lI7J3madw0tEWZuoS3b5nHfJ_oez8eSqW7oT_l6N5r8B1Q0qTA
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VogouiGcJFFik9oSsOLbXdg4IRYUqadNQiVTKzazXs4mlYIc4JvKPgt_IjF-0iMepV-_Ya3tm57Wz8zF22PNBoWF0DNcCaTgh6UHl-oZWoe9Yoac8KKt8J-7w0jmdidkO-9GchaGyykYnloo6ShXlyLtouMtm7J77bvXVINQo2l1tIDQqsTiDYoshW_Z29B75e2RZJx-mx0OjRhUwFIYiG8O3NZjgSKXNnjL7UruRKyLqo-a7SoUaJ-nJnhS-xKvoUAPYQglhg1CejTQ2PvcWu42G16Rgz5u1AR51Pi8DvL5jUf7DbArthaAcg9UlNDdBUNlXTODegmLvbfwnD_f3Qs0rlu_kPrtXu6x8UMnYA7YDyUO2V4FYFo_YdwIGLatpvwGvmiHzVPMp4LMWRYQGMl-r_Euc8DThFxnkUYr_UmZcwjqfx0maST6OVwTWUGRS0TGwOAKDMEUURHyUaBTa6oAlDwvezpbM-engrPtpOphymUR8stZWd_jR6PEL9Gq3ssg4znlOBYfzJa4yfgzLZfaYXd4Iu56w3SRN4CnjobT7eAv-Tk87YIZhX6N7KiPQdDxXig570_AlUHWHdALqWAZlpCREQFwMai522FFLvao6g_yF7rBm8X_IDhr-B7UayYJfQt9hr9thVAC0qyMTSPOSBp16B_3wDtuvxKWdyBY2unwejnjXBKkloObi10eSeFE2Gfcp0-Wbz_79Wq_YneH0fByMR5Oz5-wufVCVnzpgu5t1Di_QY9uEL8tlwtnnm16XPwFzgFR8
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9NAEF6VVEVcEG8CBRapPSErfq3tHBAKbaOkKSGCVOrNXa93E0thHeKYyD-KP8CvY8aP0CIep169E6_jeY9n5yPkwAqkAMfoGp4tueFGaAeFFxhKRIFrR77wZdnlO_YG5-7pBbvYIT-aszDYVtnYxNJQx6nAGnkHHHc5jN33Oqpui5gc998tvxqIIIVfWhs4jUpERrLYQPqWvR0eA68Pbbt_Mj0aGDXCgCEgLVkbgaOkKV0ulGkJs8uVF3ssxplqgSdEpGBDi1ucBRyuQnAtpcMEY45kwneAxoH73iK7PmZFLbL7_mQ8-dT4AZyDXqZ7XdfGaojZtN0zhhUHu4PYbgyBs684xL05ZuKb5E_x7u9tm1f8YP8euVsHsLRXSdx9siP1A7JXQVoWD8l3hAkte2u_SVqNRqapolMJ95oXMbjLfCXyL4mmqaaTTOZxCm-TZ5TLVT5LdJpxepYsEbqhyLjAQ2FJLA1EGBEypkOtQISr45Y0Kuh2Nz2jp71R5_O0N6Vcx3S8UnZn8NGw6ARi3A0vMgp7fsD2w9kCdI4eycUie0TOb4Rhj0lLp1o-JTTiThd-Aq_TV640o6irIFjlsVR4WJezNnnT8CUU9bx0hO1YhGXexFiIXAxrLrbJ4ZZ6Wc0J-QvdQc3i_5DtN_wPa6OShb9UoE1eb5fBHOA3Hq5lmpc0EOK7EJW3yZNKXLYbOcyBANCHFf-aIG0JcNT49RWdzMuR4wHWvQLz2b8f6xW5DToZng3Ho-fkDv6fqli1T1rrVS5fQPi2jl7WekLJ5U2r5k8KuloX
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Suppressive+Effect+of+Tetrahydrocurcumin+on+Pseudomonas+aeruginosa+Lipopolysaccharide-Induced+Inflammation+by+Suppressing+JAK%2FSTAT+and+Nrf2%2FHO-1+Pathways+in+Microglial+Cells&rft.jtitle=Oxidative+medicine+and+cellular+longevity&rft.au=Lin%2C+Hui-Wen&rft.au=Chen%2C+Tzu-Chun&rft.au=Yeh%2C+Jui-Hsuan&rft.au=Tsou%2C+Shang-Chun&rft.date=2022&rft.pub=Hindawi&rft.issn=1942-0900&rft.eissn=1942-0994&rft.volume=2022&rft_id=info:doi/10.1155%2F2022%2F4978556&rft_id=info%3Apmid%2F35308172&rft.externalDocID=PMC8933080
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1942-0900&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1942-0900&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1942-0900&client=summon