A role for the MutL homologue MLH2 in controlling heteroduplex formation and in regulating between two different crossover pathways in budding yeast

• Published in: Cytogenetic and genome research Vol. 107; no. 3-4; pp. 180 - 190
• Main Authors: Abdullah, M.F.F., Hoffmann, E.R., Cotton, V.E., Borts, R.H.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2004
• Subjects: Adaptor Proteins, Signal Transducing; Alleles; Cell Survival; Chromosome Segregation - genetics; Crossing Over, Genetic - genetics; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Endonucleases - genetics; Endonucleases - metabolism; Exodeoxyribonucleases - genetics; Exodeoxyribonucleases - metabolism; Fungal Proteins - genetics; Fungal Proteins - metabolism; Gene Conversion - genetics; Gene Deletion; Genotype; Models, Genetic; MutL Protein Homolog 1; MutL Proteins; MutS Homolog 3 Protein; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Nucleic Acid Heteroduplexes - genetics; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics; Saccharomyces cerevisiae Proteins - metabolism; Spores, Fungal - genetics; Spores, Fungal - metabolism

Background and aims: Mismatch repair proteins play important roles during meiotic recombination in the budding yeast Saccharomyces cerevisiae and most eukaryotic organisms studied to date. To study the functions of the mismatch repair protein Mlh2p in meiosis, we constructed mlh2Δ strains and measur...