Sickle blood contains tissue factor–positive microparticles derived from endothelial cells and monocytes

• Published in: Blood Vol. 102; no. 7; pp. 2678 - 2683
• Main Authors: Shet, Arun S., Aras, Omer, Gupta, Kalpna, Hass, Mathew J., Rausch, Douglas J., Saba, Nabil, Koopmeiners, Louann, Key, Nigel S., Hebbel, Robert P.
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.10.2003; The Americain Society of Hematology
• Subjects: Adult; Anemia, Sickle Cell - metabolism; Anemia, Sickle Cell - pathology; Anemias. Hemoglobinopathies; Annexin A5 - metabolism; Biological and medical sciences; Biomarkers; Blood Coagulation - physiology; Blood Coagulation Factors - metabolism; Diseases of red blood cells; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Female; Flow Cytometry; Hematologic and hematopoietic diseases; Humans; Male; Medical sciences; Middle Aged; Monocytes - metabolism; Monocytes - pathology; Particle Size; Thromboplastin - metabolism; Human; Hemoglobinopathy; Blood coagulation; Endothelial cell; Sickle cell anemia; Monocyte; Pathogenesis; Tissue factor; Hemopathy; Activation; Inflammation; Genetic disease; Hemolytic anemia; Sickle cell erythrocyte; Microparticle

Blood microparticles (MPs) in sickle cell disease (SCD) are reportedly derived only from erythrocytes and platelets. Yet in SCD, endothelial cells and monocytes are activated and abnormally express tissue factor (TF). Thus, sickle blood might contain TF-positive MPs derived from these cells. With th...