Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women

• Published in: Journal of the Endocrine Society Vol. 1; no. 6; pp. 625 - 637
• Main Authors: Alemán, José O., Iyengar, Neil M., Walker, Jeanne M., Milne, Ginger L., Da Rosa, Joel Correa, Liang, Yupu, Giri, Dilip D., Zhou, Xi Kathy, Pollak, Michael N., Hudis, Clifford A., Breslow, Jan L., Holt, Peter R., Dannenberg, Andrew J.
• Format: Journal Article
• Language: English
• Published: Washington, DC Endocrine Society 01.06.2017; Oxford University Press
• Subjects: Biomarkers; Body fat; Clinical s; Gastrointestinal surgery; Gene expression; Inflammation; Metabolism; Metabolites; crown-like structure; weight loss; metabolism; inflammation

Context:Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting of dead or dying adipocytes encircled by macrophages. In humans, bariatric surgery-induced weight loss leads to a decrease in CLSs, but the effects...