Ethosuximide and Phenytoin Dose-Dependently Attenuate Acute Nonconvulsive Seizures after Traumatic Brain Injury in Rats

• Published in: Journal of neurotrauma Vol. 30; no. 23; pp. 1973 - 1982
• Main Authors: Mountney, Andrea, Shear, Deborah A., Potter, Brittney, Marcsisin, Sean R., Sousa, Jason, Melendez, Victor, Tortella, Frank C., Lu, Xi-Chun M.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.12.2013
• Subjects: Animals; Anticonvulsants - pharmacokinetics; Anticonvulsants - therapeutic use; Brain - pathology; Brain damage; Brain Injuries - complications; Brain Injuries - pathology; Convulsions & seizures; Dose-Response Relationship, Drug; Drug therapy; Electroencephalography; Electroencephalography - drug effects; Ethosuximide - pharmacokinetics; Ethosuximide - therapeutic use; Head Injuries, Penetrating - complications; Head Injuries, Penetrating - pathology; Male; Original; Phenytoin - pharmacokinetics; Phenytoin - therapeutic use; Rats; Rats, Sprague-Dawley; Rodents; Seizures - drug therapy; Seizures - etiology; Trauma

Acute seizures frequently occur following severe traumatic brain injury (TBI) and have been associated with poor patient prognosis. Silent or nonconvulsive seizures (NCS) manifest in the absence of motor convulsion, can only be detected via continuous electroencephalographic (EEG) recordings, and ar...