Molecular Mechanisms of the Inhibitory Effects of Clonidine on Vascular Adenosine Triphosphate―Sensitive Potassium Channels

• Published in: Anesthesia and analgesia Vol. 113; no. 6; pp. 1374 - 1380
• Main Authors: KAWAHITO, Shinji, KAWANO, Takashi, NAKAYA, Yutaka, OSHITA, Shuzo, KITAHATA, Hiroshi, OTO, Jun, TAKAHASHI, Akira, TAKAISHI, Kazumi, HARADA, Nagakatsu, NAKAGAWA, Tadahiko, KINOSHITA, Hiroyuki, AZMA, Toshiharu
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.12.2011
• Subjects: Anesthesia; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Cell Line; Cercopithecus aethiops; Clonidine - pharmacology; COS Cells; Humans; KATP Channels - antagonists & inhibitors; KATP Channels - physiology; Medical sciences; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - physiology; Potassium Channel Blockers - pharmacology; Potassium Channels, Inwardly Rectifying - antagonists & inhibitors; Potassium Channels, Inwardly Rectifying - physiology; Rats; Imidazoline receptor; α2-Adrenergic receptor; Imidazole derivatives; Agonist; Purine nucleoside; Adenosine; Anesthesia; Antihypertensive agent; α-Adrenergic receptor agonist; Clonidine; Inorganic element; Potassium

We investigated the effects of the imidazoline-derived α2-adrenoceptor agonist clonidine on vascular adenosine triphosphate-sensitive potassium (K(ATP)) channel activity in rat vascular smooth muscle cells and recombinant vascular K(ATP) channels transiently expressed in COS-7 cells. Using the patch...