Hippocampal Subfield Volumes in Patients With First-Episode Psychosis

Abstract Background Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early...

Full description

Saved in:

Bibliographic Details
Published in	Schizophrenia bulletin Vol. 44; no. 3; pp. 552 - 559
Main Authors	Baglivo, Valentina, Cao, Bo, Mwangi, Benson, Bellani, Marcella, Perlini, Cinzia, Lasalvia, Antonio, Dusi, Nicola, Bonetto, Chiara, Cristofalo, Doriana, Alessandrini, Franco, Zoccatelli, Giada, Ciceri, Elisa, Dario, Lamonaca, Enrico, Ceccato, Francesca, Pileggi, Mazzi, Fausto, Paolo, Santonastaso, Balestrieri, Matteo, Soares, Jair C, Ruggeri, Mirella, Brambilla, Paolo
Format	Journal Article
Language	English
Published	US Oxford University Press 06.04.2018
Subjects	Adult Bipolar Disorder - diagnostic imaging Bipolar Disorder - pathology CA1 Region, Hippocampal - diagnostic imaging CA1 Region, Hippocampal - pathology CA3 Region, Hippocampal - diagnostic imaging CA3 Region, Hippocampal - pathology Female Hippocampus - diagnostic imaging Hippocampus - pathology Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Middle Aged Psychosis Psychotic Disorders - diagnostic imaging Psychotic Disorders - pathology Regular Schizophrenia - diagnostic imaging Schizophrenia - pathology Schizotypal Personality Disorder - diagnostic imaging Schizotypal Personality Disorder - pathology Young Adult schizophrenia hippocampus volumetry psychotic bipolar disorder
Online Access	Get full text
ISSN	0586-7614 1745-1701 1745-1701
DOI	10.1093/schbul/sbx108

Cover

Abstract	Abstract Background Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis. Aim The aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP). Methods Magnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates. Results We found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS). Conclusion We report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset.
AbstractList	Abstract Background Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis. Aim The aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP). Methods Magnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates. Results We found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS). Conclusion We report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset. Background Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis. Aim The aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP). Methods Magnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates. Results We found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS). Conclusion We report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset. Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis.BackgroundHippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis.The aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP).AimThe aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP).Magnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates.MethodsMagnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates.We found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS).ResultsWe found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS).We report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset.ConclusionWe report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset. Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the pathophysiology of the psychosis. The hippocampus consists of several subfields but it remains unclear their involvement in the early stages of psychosis. The aim of this study was to investigate volumetric alterations in hippocampal subfields in patients at the first-episode psychosis (FEP). Magnetic resonance imaging (MRI) data were collected in 134 subjects (58 FEP patients; 76 healthy controls [HC]). A novel automated hippocampal segmentation algorithm was used to segment the hippocampal subfields, based on an atlas constructed from ultra-high resolution imaging on ex vivo hippocampal tissue. The general linear model was used to investigate volume differences between FEP patients and HC, with age, gender and total intracranial volume as covariates. We found significantly lower volumes of bilateral CA1, CA4, and granule cell layer (GCL), and of left CA3, and left molecular layer (ML) in FEP patients compared to HC. Only the volumes of the left hippocampus and its subfields were significantly lower in FEP than HC at the False Discovery Rate (FDR) of 0.1. No correlation was found between hippocampal subfield volume and duration of illness, age of onset, duration of medication, and Positive and Negative Syndrome Scale (PANSS). We report abnormally low volumes of left hippocampal subfields in patients with FEP, sustaining its role as a putative neural marker of psychosis onset.
Author	Balestrieri, Matteo Perlini, Cinzia Bonetto, Chiara Dusi, Nicola Baglivo, Valentina Paolo, Santonastaso Ruggeri, Mirella Cao, Bo Francesca, Pileggi Cristofalo, Doriana Alessandrini, Franco Zoccatelli, Giada Ciceri, Elisa Enrico, Ceccato Brambilla, Paolo Lasalvia, Antonio Soares, Jair C Dario, Lamonaca Mwangi, Benson Bellani, Marcella Mazzi, Fausto
AuthorAffiliation	12 Department of Neuroscience, University of Padova, Padova, Italy 8 Department of Psychiatry, CSM AULSS 21 Legnago, Verona, Italy 1 Unit of Psychiatry, Department of Medicine, University of Udine, Udine, Italy 5 Department of Public Health and Community Medicine, Section of Clinical Psychology, University of Verona, Verona, Italy 11 Department of Mental Health, Modena, Italy 10 Department of Mental Health, Azienda ULSS Bologna, Bologna, Italy 2 UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 3 UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy 4 InterUniversity Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy 7 Neuroradiology Department, Azienda Ospedaliera Universitaria, Verona, Italy 6 Section of Psychiatry, Department of Neurological, Biomedical and Movement Sciences, University of Ver
AuthorAffiliation_xml	– name: 1 Unit of Psychiatry, Department of Medicine, University of Udine, Udine, Italy – name: 13 Department of Neurosciences and Mental Health, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy – name: 12 Department of Neuroscience, University of Padova, Padova, Italy – name: 9 Department of Mental Health, Hospital of Montecchio Maggiore, Vicenza, Italy – name: 8 Department of Psychiatry, CSM AULSS 21 Legnago, Verona, Italy – name: 2 UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX – name: 11 Department of Mental Health, Modena, Italy – name: 7 Neuroradiology Department, Azienda Ospedaliera Universitaria, Verona, Italy – name: 3 UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy – name: 5 Department of Public Health and Community Medicine, Section of Clinical Psychology, University of Verona, Verona, Italy – name: 6 Section of Psychiatry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy – name: 4 InterUniversity Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy – name: 10 Department of Mental Health, Azienda ULSS Bologna, Bologna, Italy
Author_xml	– sequence: 1 givenname: Valentina surname: Baglivo fullname: Baglivo, Valentina organization: Unit of Psychiatry, Department of Medicine, University of Udine, Udine, Italy – sequence: 2 givenname: Bo surname: Cao fullname: Cao, Bo organization: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX – sequence: 3 givenname: Benson surname: Mwangi fullname: Mwangi, Benson organization: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX – sequence: 4 givenname: Marcella surname: Bellani fullname: Bellani, Marcella organization: UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy – sequence: 5 givenname: Cinzia surname: Perlini fullname: Perlini, Cinzia organization: InterUniversity Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy – sequence: 6 givenname: Antonio surname: Lasalvia fullname: Lasalvia, Antonio organization: UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy – sequence: 7 givenname: Nicola surname: Dusi fullname: Dusi, Nicola organization: UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy – sequence: 8 givenname: Chiara surname: Bonetto fullname: Bonetto, Chiara organization: Section of Psychiatry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy – sequence: 9 givenname: Doriana surname: Cristofalo fullname: Cristofalo, Doriana organization: Section of Psychiatry, Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy – sequence: 10 givenname: Franco surname: Alessandrini fullname: Alessandrini, Franco organization: Neuroradiology Department, Azienda Ospedaliera Universitaria, Verona, Italy – sequence: 11 givenname: Giada surname: Zoccatelli fullname: Zoccatelli, Giada organization: Neuroradiology Department, Azienda Ospedaliera Universitaria, Verona, Italy – sequence: 12 givenname: Elisa surname: Ciceri fullname: Ciceri, Elisa organization: Neuroradiology Department, Azienda Ospedaliera Universitaria, Verona, Italy – sequence: 13 givenname: Lamonaca surname: Dario fullname: Dario, Lamonaca organization: Department of Psychiatry, CSM AULSS 21 Legnago, Verona, Italy – sequence: 14 givenname: Ceccato surname: Enrico fullname: Enrico, Ceccato organization: Department of Mental Health, Hospital of Montecchio Maggiore, Vicenza, Italy – sequence: 15 givenname: Pileggi surname: Francesca fullname: Francesca, Pileggi organization: Department of Mental Health, Azienda ULSS Bologna, Bologna, Italy – sequence: 16 givenname: Fausto surname: Mazzi fullname: Mazzi, Fausto organization: Department of Mental Health, Modena, Italy – sequence: 17 givenname: Santonastaso surname: Paolo fullname: Paolo, Santonastaso email: paolo.brambilla1@unimi.it organization: Department of Neuroscience, University of Padova, Padova, Italy – sequence: 18 givenname: Matteo surname: Balestrieri fullname: Balestrieri, Matteo organization: Unit of Psychiatry, Department of Medicine, University of Udine, Udine, Italy – sequence: 19 givenname: Jair C surname: Soares fullname: Soares, Jair C organization: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX – sequence: 20 givenname: Mirella surname: Ruggeri fullname: Ruggeri, Mirella organization: UOC Psychiatry, Azienda Ospedaliera Universitaria Integrata Verona (AOUI), Verona, Italy – sequence: 21 givenname: Paolo surname: Brambilla fullname: Brambilla, Paolo email: paolo.brambilla1@unimi.it organization: UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/29897598$$D View this record in MEDLINE/PubMed
BookMark	eNqFkc1LHTEUxYNY9Gm7dCsD3XQzNZl8TTZCkecHCBW07TLka3yRzGScO1P0v3ce71VaQbq6i_xy7jn3HKDdLncBoSOCvxKs6Am4lZ3SCdgngusdtCCS8ZJITHbRAvNalFIQto8OAB4wJkyJag_tV6pWkqt6gZaXse-zM21vUnE72SaG5IufOU1tgCJ2xY0ZY-hGKH7FcVWcxwHGctlHyD4UN_DsVhkifEQfGpMgfNrOQ_TjfHl3dllef7-4Ovt2XTrG6rEU1knrG2epZZh5LxmjnnhHZ2eSU0ltxTkjjhHShMpTL6iovWm8I8YLV9FDdLrR7SfbBu9mY4NJuh9ia4ZnnU3U_750caXv82_Na4WZFLPAl63AkB-nAKNuI7iQkulCnkBXmDNFKcd8Rj-_QR_yNHRzPE2JqiqhpFg7Ov7b0auVPxeegXIDuCEDDKF5RQjW6wb1pkG9aXDm6RvexXHuIK8DxfTur22uPPX_WfACTb-xMA
CitedBy_id	crossref_primary_10_1002_hbm_25276 crossref_primary_10_1002_hbm_24464 crossref_primary_10_1017_S0033291719001144 crossref_primary_10_1007_s11682_018_9879_z crossref_primary_10_1038_s41398_020_0812_z crossref_primary_10_1016_j_nicl_2022_103087 crossref_primary_10_1016_j_schres_2019_01_030 crossref_primary_10_1007_s00406_023_01554_5 crossref_primary_10_1016_j_jpsychires_2022_05_006 crossref_primary_10_1038_s41398_024_02746_w crossref_primary_10_1016_j_schres_2021_12_037 crossref_primary_10_1038_s41380_019_0443_z crossref_primary_10_1016_j_psychres_2020_113508 crossref_primary_10_3389_fnana_2023_1114757 crossref_primary_10_1016_j_pnpbp_2020_110047 crossref_primary_10_1093_schbul_sbaa099 crossref_primary_10_1016_j_pscychresns_2020_111084 crossref_primary_10_1038_s41386_021_00997_5 crossref_primary_10_1016_j_bpsgos_2022_02_003 crossref_primary_10_1111_pcn_12985 crossref_primary_10_1007_s00406_020_01140_z crossref_primary_10_1016_j_jpsychires_2020_09_012 crossref_primary_10_1038_s41398_023_02449_8 crossref_primary_10_1038_s41380_024_02812_1 crossref_primary_10_1177_1535759719868459 crossref_primary_10_1016_j_pnpbp_2021_110291 crossref_primary_10_1016_j_euroneuro_2020_03_020 crossref_primary_10_1016_j_rcp_2023_04_005 crossref_primary_10_3389_fnins_2023_1153439 crossref_primary_10_1016_j_bionps_2020_100026 crossref_primary_10_1002_hbm_26224 crossref_primary_10_1016_j_neuroimage_2019_05_017 crossref_primary_10_1002_hipo_23215 crossref_primary_10_3389_fpsyt_2021_642048 crossref_primary_10_1017_S0033291718003458 crossref_primary_10_1016_j_pnpbp_2021_110297 crossref_primary_10_1016_j_jpsychires_2021_01_044 crossref_primary_10_3233_JAD_200804 crossref_primary_10_3389_fpsyt_2023_1092213 crossref_primary_10_1016_j_psyneuen_2024_107149 crossref_primary_10_1002_hbm_25326 crossref_primary_10_1002_hbm_25601 crossref_primary_10_1017_S1092852918001293 crossref_primary_10_2174_1381612828666220428102802 crossref_primary_10_1016_j_bionps_2021_100037 crossref_primary_10_1038_s41398_019_0618_z crossref_primary_10_1038_s41386_019_0542_1 crossref_primary_10_1523_ENEURO_0375_20_2021 crossref_primary_10_1016_j_pscychresns_2025_111968 crossref_primary_10_1002_npr2_12031 crossref_primary_10_1038_s41537_024_00475_z crossref_primary_10_1093_schbul_sbz116 crossref_primary_10_1016_j_pscychresns_2021_111249 crossref_primary_10_1016_j_bbi_2021_05_009 crossref_primary_10_1210_clinem_dgae070 crossref_primary_10_1016_j_bpsc_2020_04_014 crossref_primary_10_3389_fpsyt_2020_614659 crossref_primary_10_1111_bdi_12710
Cites_doi	10.1016/j.neuroimage.2015.04.042 10.1176/ajp.154.6.812 10.1038/npp.2017.5 10.1016/j.biopsych.2015.02.029 10.1101/lm.794808 10.1006/nimg.1998.0395 10.1016/j.schres.2007.05.041 10.1016/S0896-6273(02)00569-X 10.1002/hipo.10177 10.1016/j.schres.2007.05.002 10.1093/hmg/ddp266 10.1016/j.biopsych.2004.01.004 10.1001/archpsyc.56.2.133 10.1001/jamapsychiatry.2014.453 10.1016/j.neuron.2008.09.023 10.1016/S0140-6736(09)60072-6 10.1371/journal.pgen.1003455 10.1038/4151030a 10.1038/mp.2016.262 10.1176/appi.ajp.2010.09081187 10.1017/S2045796016000275 10.1073/pnas.97.20.11032 10.1016/S0006-3223(98)00138-3 10.1002/hipo.1070 10.1093/brain/aws335 10.1192/bjp.191.51.s31 10.1126/science.1114037 10.1093/schbul/sbq108 10.1038/tp.2012.51 10.1016/j.neuroscience.2004.04.026 10.1007/978-3-662-03628-0 10.1038/sj.mp.4001558 10.1016/j.neuron.2013.02.011 10.1002/hbm.22825 10.1017/S0033291709992297 10.1186/1745-6215-13-73 10.1016/j.tics.2013.03.005 10.1016/j.psychres.2004.11.003 10.1038/sj.mp.4000783 10.1136/jmg.2005.030718 10.1093/schbul/sbv058 10.1016/0920-9964(95)00028-K 10.1016/j.biopsych.2005.03.031 10.1001/archpsyc.65.9.1017 10.1192/bjp.bp.111.105700 10.1016/j.biopsych.2010.03.036 10.1093/schbul/sbp034 10.1007/s10571-006-9128-7 10.1016/j.euroneuro.2003.12.005 10.3389/fnagi.2014.00261 10.1001/archgenpsychiatry.2010.175 10.1002/hipo.20615 10.1016/j.biopsych.2004.12.009 10.1016/j.biopsych.2014.06.020 10.1038/mp.2016.4 10.1093/schbul/sbp020
ContentType	Journal Article
Copyright	The Author(s) 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017 The Author(s) 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Copyright_xml	– notice: The Author(s) 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017 – notice: The Author(s) 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com.
CorporateAuthor	GET UP Group
CorporateAuthor_xml	– name: GET UP Group
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7RV 7XB 88G 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ KB0 M2M NAPCQ PHGZM PHGZT PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 5PM
DOI	10.1093/schbul/sbx108
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Nursing & Allied Health Database ProQuest Central (purchase pre-March 2016) Psychology Database (Alumni) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Nursing & Allied Health Database (Alumni Edition) Psychology Database Nursing & Allied Health Premium ProQuest Central Premium ProQuest One Academic ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Central China ProQuest Central Health Research Premium Collection ProQuest Central Korea ProQuest Central (New) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Nursing & Allied Health Source ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) ProQuest Hospital Collection (Alumni) Nursing & Allied Health Premium ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest Nursing & Allied Health Source (Alumni) ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic
DatabaseTitleList	ProQuest One Psychology MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: http://www.proquest.com/pqcentral?accountid=15518 sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
EISSN	1745-1701
EndPage	559
ExternalDocumentID	PMC5890476 29897598 10_1093_schbul_sbx108 10.1093/schbul/sbx108
Genre	Research Support, Non-U.S. Gov't Journal Article
GrantInformation_xml	– fundername: Ministry of Health funderid: 10.13039/100009647 – fundername: ; ; ;
GroupedDBID	--- -E4 -~X .2P .I3 .XZ .ZR 0R~ 123 18M 2WC 4.4 48X 53G 5RE 5VS 5WA 5WD 70D 7RZ 85S AABZA AACZT AAJKP AAJQQ AAMDB AAMVS AAOGV AAPNW AAPQZ AAPXW AARHZ AASNB AAUAY AAUQX AAVAP AAWTL ABEUO ABIVO ABIXL ABJNI ABKDP ABLJU ABNHQ ABNKS ABOCM ABPPZ ABPTD ABQLI ABQNK ABWST ABXVV ABZBJ ACGFO ACGFS ACGOD ACHQT ACNCT ACUFI ACUTJ ACUTO ACYHN ADBBV ADEYI ADEZT ADGZP ADHKW ADHZD ADIPN ADJQC ADOCK ADQBN ADRIX ADRTK ADVEK ADYVW ADZXQ AEGPL AEGXH AEJOX AEKSI AEMDU AENEX AENZO AEPUE AETBJ AEWNT AFFZL AFIYH AFOFC AFXAL AFXEN AGINJ AGKEF AGQXC AGSYK AGUTN AHMBA AHXPO AIAGR AIJHB AJEEA AKWXX ALMA_UNASSIGNED_HOLDINGS ALUQC AOIJS APIBT APWMN ATGXG AXUDD BAWUL BAYMD BCRHZ BEYMZ BHONS BTRTY BVRKM C45 CDBKE CGNQK CS3 CZ4 DAKXR DIK DILTD DU5 D~K E3Z EBD EBS EE~ EJD EMOBN ENERS EPA F5P F9B FECEO FLUFQ FOEOM FOTVD FQBLK GAUVT GJXCC GX1 H13 H5~ HAR HW0 HYE HZ~ IOX J21 KBUDW KOP KSI KSN M-Z M49 MHKGH N9A NGC NOMLY NOYVH NU- O9- OAUYM OAWHX OCZFY ODMLO OJQWA OJZSN OK1 OPA OPAEJ OVD OWPYF P2P PAFKI PEELM PQQKQ Q1. Q5Y RD5 ROL ROX ROZ RPM RUSNO RW1 RXO SV3 TEORI TJX TN5 TR2 TWZ W8F WH7 WOQ X7H YAYTL YKOAZ YNT YROCO YXANX YZZ ZKX ~91 7RV 8FI 8FJ AAILS AAYXX ABDFA ABEJV ABGNP ABPQP ABUWG ABVGC ADCFL ADNBA AEHKS AEMQT AFKRA AGORE AHMMS AJBYB AJNCP ALXQX AZQEC BENPR CCPQU CITATION DWQXO FYUFA GNUQQ JXSIZ M2M NAPCQ PHGZM PHGZT PSYQQ UKHRP CGR CUY CVF ECM EIF NPM 3V. 7XB 8FK PKEHL PPXIY PQEST PQUKI PRINS Q9U 7X8 1TH 5PM
ID	FETCH-LOGICAL-c448t-6bc7bdfcb3b404dd7443d1dc300175373b25541c411fe2d3d6368dafdc1ad6c23
IEDL.DBID	BENPR
ISSN	0586-7614 1745-1701
IngestDate	Thu Aug 21 18:10:24 EDT 2025 Thu Jul 10 23:19:28 EDT 2025 Fri Jul 25 20:50:25 EDT 2025 Thu Apr 03 07:08:23 EDT 2025 Tue Jul 01 02:40:47 EDT 2025 Thu Apr 24 23:01:41 EDT 2025 Wed Sep 11 04:48:52 EDT 2024
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	3
Keywords	schizophrenia hippocampus volumetry psychotic bipolar disorder
Language	English
License	This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/about_us/legal/notices) https://academic.oup.com/journals/pages/about_us/legal/notices
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c448t-6bc7bdfcb3b404dd7443d1dc300175373b25541c411fe2d3d6368dafdc1ad6c23
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 These authors contributed equally to this work.
OpenAccessLink	https://academic.oup.com/schizophreniabulletin/article-pdf/44/3/552/24566225/sbx108.pdf
PMID	29897598
PQID	3192269762
PQPubID	6438235
PageCount	8
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_5890476 proquest_miscellaneous_2054933505 proquest_journals_3192269762 pubmed_primary_29897598 crossref_primary_10_1093_schbul_sbx108 crossref_citationtrail_10_1093_schbul_sbx108 oup_primary_10_1093_schbul_sbx108
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2018-04-06
PublicationDateYYYYMMDD	2018-04-06
PublicationDate_xml	– month: 04 year: 2018 text: 2018-04-06 day: 06
PublicationDecade	2010
PublicationPlace	US
PublicationPlace_xml	– name: US – name: United States – name: Oxford
PublicationTitle	Schizophrenia bulletin
PublicationTitleAlternate	Schizophr Bull
PublicationYear	2018
Publisher	Oxford University Press
Publisher_xml	– name: Oxford University Press
References	Cong ( key 20180406155404_CIT0034) 2014; 2014 Haukvik ( key 20180406155404_CIT0013) 2015; 77 Moncrieff ( key 20180406155404_CIT0011) 2010; 40 Van Leemput ( key 20180406155404_CIT0028) 2009; 19 Andreassen ( key 20180406155404_CIT0055) 2013; 9 Strasser ( key 20180406155404_CIT0052) 2005; 57 Schultze-lutter ( key 20180406155404_CIT0003) 2007; 191 Ho ( key 20180406155404_CIT0015) 2017; 22 Rimol ( key 20180406155404_CIT0054) 2010; 68 Lichtenstein ( key 20180406155404_CIT0056) 2009; 373 Velakoulis ( key 20180406155404_CIT0049) 1999; 56 Kühn ( key 20180406155404_CIT0029) 2012; 2 Medoff ( key 20180406155404_CIT0005) 2001; 11 Joshi ( key 20180406155404_CIT0033) 2016; 79 Weickert ( key 20180406155404_CIT0045) 2008; 98 Cuthbert ( key 20180406155404_CIT0058) 2010; 36 Ho ( key 20180406155404_CIT0016) 2017; 42 Rioux ( key 20180406155404_CIT0046) 2005; 133 Poppenk ( key 20180406155404_CIT0035) 2013; 17 Dale ( key 20180406155404_CIT0025) 1999; 9 Meyer ( key 20180406155404_CIT0047) 2009; 18 Benes ( key 20180406155404_CIT0018) 1998; 44 Simonsen ( key 20180406155404_CIT0053) 2011; 37 Liu ( key 20180406155404_CIT0020) 2007; 27 Voineskos ( key 20180406155404_CIT0031) 2015; 36 Konradi ( key 20180406155404_CIT0019) 2011; 68 Craddock ( key 20180406155404_CIT0057) 2009; 35 Fischl ( key 20180406155404_CIT0026) 2002; 33 Brambilla ( key 20180406155404_CIT0010) 2013; 202 Sala ( key 20180406155404_CIT0012) 2004; 14 Zaidel ( key 20180406155404_CIT0017) 1997; 154 Amaral ( key 20180406155404_CIT0021) 2007 Harrison ( key 20180406155404_CIT0043) 2005; 10 Lee ( key 20180406155404_CIT0038) 2004; 14 Law ( key 20180406155404_CIT0044) 2004; 127 Shohamy ( key 20180406155404_CIT0006) 2008; 60 Altar ( key 20180406155404_CIT0042) 2005; 58 Ruggeri ( key 20180406155404_CIT0024) 2015; 41 Tamminga ( key 20180406155404_CIT0004) 2010; 167 Kempton ( key 20180406155404_CIT0050) 2008; 65 Fatemi ( key 20180406155404_CIT0040) 2000; 5 Iglesias ( key 20180406155404_CIT0022) 2015; 115 Mathew ( key 20180406155404_CIT0051) 2014; 71 Ruggeri ( key 20180406155404_CIT0023) 2012; 13 Weiss ( key 20180406155404_CIT0007) 2004; 55 Bilder ( key 20180406155404_CIT0027) 1995; 17 Leutgeb ( key 20180406155404_CIT0039) 2005; 309 Maggioni ( key 20180406155404_CIT0001) 2016; 25 van Praag ( key 20180406155404_CIT0041) 2002; 415 Wisse ( key 20180406155404_CIT0036) 2014; 6 Craddock ( key 20180406155404_CIT0002) 2005; 42 Lemaire ( key 20180406155404_CIT0048) 2000; 97 Zierhut ( key 20180406155404_CIT0009) 2013; 136 Duvernoy ( key 20180406155404_CIT0014) 1998 Panenka ( key 20180406155404_CIT0008) 2007; 94 Schobel ( key 20180406155404_CIT0030) 2013; 78 Ji ( key 20180406155404_CIT0037) 2008; 15 Cao ( key 20180406155404_CIT0032) 2017 19405131 - Hippocampus. 2009 Jun;19(6):549-57 11005874 - Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11032-7 22647399 - Trials. 2012 May 30;13:73 15698673 - Psychiatry Res. 2005 Jan 30;133(1):13-21 22692142 - Transl Psychiatry. 2012 Jun 12;2:e127 17570643 - Schizophr Res. 2007 Aug;94(1-3):288-92 9931268 - Neuroimage. 1999 Feb;9(2):179-94 11875571 - Nature. 2002 Feb 28;415(6875):1030-4 17235693 - Cell Mol Neurobiol. 2007 May;27(3):351-8 23597720 - Trends Cogn Sci. 2013 May;17(5):230-40 20609836 - Biol Psychiatry. 2010 Jul 1;68(1):41-50 24828364 - JAMA Psychiatry. 2014 Jul 1;71(7):769-77 25995057 - Schizophr Bull. 2015 Sep;41(5):1192-203 15263907 - Mol Psychiatry. 2005 Jan;10(1):40-68; image 5 23284150 - Br J Psychiatry. 2013 Jan;202(1):50-5 25127742 - Biol Psychiatry. 2015 Mar 15;77(6):581-8 21135314 - Arch Gen Psychiatry. 2011 Apr;68(4):340-50 17765709 - Prog Brain Res. 2007;163:3-22 16040709 - Science. 2005 Jul 22;309(5734):619-23 16038679 - Biol Psychiatry. 2005 Jul 15;58(2):85-96 20929969 - Schizophr Bull. 2010 Nov;36(6):1061-2 15219675 - Neuroscience. 2004;127(1):125-36 8541249 - Schizophr Res. 1995 Sep;17(1):47-58 9646890 - Biol Psychiatry. 1998 Jul 15;44(2):88-97 11732707 - Hippocampus. 2001;11(5):543-50 15132429 - Hippocampus. 2004;14(3):301-10 15336301 - Eur Neuropsychopharmacol. 2004 Oct;14(5):393-405 23388407 - Brain. 2013 Mar;136(Pt 3):804-14 17961984 - Schizophr Res. 2008 Jan;98(1-3):105-10 23637625 - PLoS Genet. 2013 Apr;9(4):e1003455 19329560 - Schizophr Bull. 2009 May;35(3):482-90 18957228 - Neuron. 2008 Oct 23;60(2):378-89 11832223 - Neuron. 2002 Jan 31;33(3):341-55 28079061 - Neuropsychopharmacology. 2017 May;42(6):1361-1370 20085668 - Psychol Med. 2010 Sep;40(9):1409-22 26903271 - Mol Psychiatry. 2017 Jan;22(1):142-152 18762588 - Arch Gen Psychiatry. 2008 Sep;65(9):1017-32 25477768 - Conf Proc (Midwest Symp Circuits Syst). 2014 Aug;2014:813-816 27095442 - Epidemiol Psychiatr Sci. 2016 Aug;25(4):312-6 15744031 - J Med Genet. 2005 Mar;42(3):193-204 19443616 - Schizophr Bull. 2011 Jan;37(1):73-83 25842202 - Biol Psychiatry. 2016 Feb 15;79(4):282-92 20810471 - Am J Psychiatry. 2010 Oct;167(10):1178-93 25309437 - Front Aging Neurosci. 2014 Sep 25;6:261 25936807 - Neuroimage. 2015 Jul 15;115:117-37 25959503 - Hum Brain Mapp. 2015 Aug;36(8):3020-37 28115740 - Mol Psychiatry. 2017 Sep;22(9):1352-1358 19502360 - Hum Mol Genet. 2009 Sep 1;18(17):3286-97 11126396 - Mol Psychiatry. 2000 Nov;5(6):654-63, 571 9167509 - Am J Psychiatry. 1997 Jun;154(6):812-8 23583108 - Neuron. 2013 Apr 10;78(1):81-93 19150704 - Lancet. 2009 Jan 17;373(9659):234-9 15038994 - Biol Psychiatry. 2004 Apr 1;55(7):668-75 18391185 - Learn Mem. 2008 Apr 03;15(4):244-51 10025437 - Arch Gen Psychiatry. 1999 Feb;56(2):133-41 15780850 - Biol Psychiatry. 2005 Mar 15;57(6):633-9
References_xml	– volume: 115 start-page: 117 year: 2015 ident: key 20180406155404_CIT0022 article-title: A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: application to adaptive segmentation of in vivo MRI publication-title: Neuroimage doi: 10.1016/j.neuroimage.2015.04.042 – volume: 154 start-page: 812 year: 1997 ident: key 20180406155404_CIT0017 article-title: Size, shape, and orientation of neurons in the left and right hippocampus: investigation of normal asymmetries and alterations in schizophrenia publication-title: Am J Psychiatry doi: 10.1176/ajp.154.6.812 – volume: 42 start-page: 1361 year: 2017 ident: key 20180406155404_CIT0016 article-title: Progressive decline in hippocampal CA1 volume in individuals at ultra-high-risk for psychosis who do not remit: findings from the longitudinal youth at risk study publication-title: Neuropsychopharmacology doi: 10.1038/npp.2017.5 – volume: 79 start-page: 282 year: 2016 ident: key 20180406155404_CIT0033 article-title: Structural plasticity of the hippocampus and amygdala induced by electroconvulsive therapy in major depression publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2015.02.029 – volume: 15 start-page: 244 year: 2008 ident: key 20180406155404_CIT0037 article-title: Differential roles for hippocampal areas CA1 and CA3 in the contextual encoding and retrieval of extinguished fear publication-title: Learn Mem doi: 10.1101/lm.794808 – volume: 9 start-page: 179 year: 1999 ident: key 20180406155404_CIT0025 article-title: Cortical surface-based analysis publication-title: Neuroimage doi: 10.1006/nimg.1998.0395 – volume: 98 start-page: 105 year: 2008 ident: key 20180406155404_CIT0045 article-title: Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients publication-title: Schizophr Res doi: 10.1016/j.schres.2007.05.041 – volume: 33 start-page: 341 year: 2002 ident: key 20180406155404_CIT0026 article-title: Whole brain segmentation publication-title: Neuron doi: 10.1016/S0896-6273(02)00569-X – volume: 14 start-page: 301 year: 2004 ident: key 20180406155404_CIT0038 article-title: Differential contributions of dorsal hippocampal subregions to memory acquisition and retrieval in contextual fear-conditioning publication-title: Hippocampus doi: 10.1002/hipo.10177 – volume: 94 start-page: 288 year: 2007 ident: key 20180406155404_CIT0008 article-title: A longitudinal study on the effects of typical versus atypical antipsychotic drugs on hippocampal volume in schizophrenia publication-title: Schizophr Res doi: 10.1016/j.schres.2007.05.002 – volume: 18 start-page: 3286 year: 2009 ident: key 20180406155404_CIT0047 article-title: Disc1 regulates granule cell migration in the developing hippocampus publication-title: Hum Mol Genet doi: 10.1093/hmg/ddp266 – volume: 55 start-page: 668 year: 2004 ident: key 20180406155404_CIT0007 article-title: Impaired hippocampal function during the detection of novel words in schizophrenia publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2004.01.004 – start-page: 3 year: 2007 ident: key 20180406155404_CIT0021 article-title: The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies) – volume: 56 start-page: 133 year: 1999 ident: key 20180406155404_CIT0049 article-title: Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.56.2.133 – volume: 71 start-page: 769 year: 2014 ident: key 20180406155404_CIT0051 article-title: Medial temporal lobe structures and hippocampal subfields in psychotic disorders: findings from the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) study publication-title: JAMA Psychiatry doi: 10.1001/jamapsychiatry.2014.453 – volume: 60 start-page: 378 year: 2008 ident: key 20180406155404_CIT0006 article-title: Integrating memories in the human brain: hippocampal-midbrain encoding of overlapping events publication-title: Neuron doi: 10.1016/j.neuron.2008.09.023 – volume: 373 start-page: 234 year: 2009 ident: key 20180406155404_CIT0056 article-title: Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study publication-title: Lancet doi: 10.1016/S0140-6736(09)60072-6 – volume: 9 start-page: e1003455 year: 2013 ident: key 20180406155404_CIT0055 article-title: Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate publication-title: PLoS Genet doi: 10.1371/journal.pgen.1003455 – volume: 2014 start-page: 813 year: 2014 ident: key 20180406155404_CIT0034 article-title: Building a surface atlas of hippocampal subfields from MRI scans using FreeSurfer, FIRST and SPHARM publication-title: Conf Proc (Midwest Symp Circuits Syst) – volume: 415 start-page: 1030 year: 2002 ident: key 20180406155404_CIT0041 article-title: Functional neurogenesis in the adult hippocampus publication-title: Nature doi: 10.1038/4151030a – year: 2017 ident: key 20180406155404_CIT0032 article-title: Hippocampal subfield volumes in mood disorders publication-title: Mol Psychiatry doi: 10.1038/mp.2016.262 – volume: 167 start-page: 1178 year: 2010 ident: key 20180406155404_CIT0004 article-title: The hippocampal formation in schizophrenia publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.2010.09081187 – volume: 25 start-page: 312 year: 2016 ident: key 20180406155404_CIT0001 article-title: Neuroanatomical voxel-based profile of schizophrenia and bipolar disorder publication-title: Epidemiol Psychiatr Sci doi: 10.1017/S2045796016000275 – volume: 97 start-page: 11032 year: 2000 ident: key 20180406155404_CIT0048 article-title: Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.97.20.11032 – volume: 44 start-page: 88 year: 1998 ident: key 20180406155404_CIT0018 article-title: A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives publication-title: Biol Psychiatry doi: 10.1016/S0006-3223(98)00138-3 – volume: 11 start-page: 543 year: 2001 ident: key 20180406155404_CIT0005 article-title: Probing the human hippocampus using rCBF: contrasts in schizophrenia publication-title: Hippocampus doi: 10.1002/hipo.1070 – volume: 136 start-page: 804 year: 2013 ident: key 20180406155404_CIT0009 article-title: Hippocampal CA1 deformity is related to symptom severity and antipsychotic dosage in schizophrenia publication-title: Brain doi: 10.1093/brain/aws335 – volume: 191 start-page: s31 year: 2007 ident: key 20180406155404_CIT0003 article-title: Basic symptoms in early psychotic and depressive disorders publication-title: Br J Psychiatry doi: 10.1192/bjp.191.51.s31 – volume: 309 start-page: 619 year: 2005 ident: key 20180406155404_CIT0039 article-title: Independent codes for spatial and episodic memory in hippocampal neuronal ensembles publication-title: Science doi: 10.1126/science.1114037 – volume: 36 start-page: 1061 year: 2010 ident: key 20180406155404_CIT0058 article-title: Toward new approaches to psychotic disorders: the NIMH Research Domain Criteria project publication-title: Schizophr Bull doi: 10.1093/schbul/sbq108 – volume: 2 start-page: e127 year: 2012 ident: key 20180406155404_CIT0029 article-title: Hippocampal subfields predict positive symptoms in schizophrenia: first evidence from brain morphometry publication-title: Transl Psychiatry doi: 10.1038/tp.2012.51 – volume: 127 start-page: 125 year: 2004 ident: key 20180406155404_CIT0044 article-title: Neuregulin-1 (NRG-1) mRNA and protein in the adult human brain publication-title: Neuroscience doi: 10.1016/j.neuroscience.2004.04.026 – volume-title: The Human Hippocampus year: 1998 ident: key 20180406155404_CIT0014 doi: 10.1007/978-3-662-03628-0 – volume: 10 start-page: 40 year: 2005 ident: key 20180406155404_CIT0043 article-title: Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001558 – volume: 78 start-page: 81 year: 2013 ident: key 20180406155404_CIT0030 article-title: Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver publication-title: Neuron doi: 10.1016/j.neuron.2013.02.011 – volume: 36 start-page: 3020 year: 2015 ident: key 20180406155404_CIT0031 article-title: Hippocampal (subfield) volume and shape in relation to cognitive performance across the adult lifespan publication-title: Hum Brain Mapp doi: 10.1002/hbm.22825 – volume: 40 start-page: 1409 year: 2010 ident: key 20180406155404_CIT0011 article-title: A systematic review of the effects of antipsychotic drugs on brain volume publication-title: Psychol Med doi: 10.1017/S0033291709992297 – volume: 13 start-page: 73 year: 2012 ident: key 20180406155404_CIT0023 article-title: A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial publication-title: Trials doi: 10.1186/1745-6215-13-73 – volume: 17 start-page: 230 year: 2013 ident: key 20180406155404_CIT0035 article-title: Long-axis specialization of the human hippocampus publication-title: Trends Cogn Sci doi: 10.1016/j.tics.2013.03.005 – volume: 133 start-page: 13 year: 2005 ident: key 20180406155404_CIT0046 article-title: The expression of retinoic acid receptor alpha is increased in the granule cells of the dentate gyrus in schizophrenia publication-title: Psychiatry Res doi: 10.1016/j.psychres.2004.11.003 – volume: 5 start-page: 654 year: 2000 ident: key 20180406155404_CIT0040 article-title: Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4000783 – volume: 42 start-page: 193 year: 2005 ident: key 20180406155404_CIT0002 article-title: The genetics of schizophrenia and bipolar disorder: dissecting psychosis publication-title: J Med Genet doi: 10.1136/jmg.2005.030718 – volume: 41 start-page: 1192 year: 2015 ident: key 20180406155404_CIT0024 article-title: Feasibility and effectiveness of a multi-element psychosocial intervention for first-episode psychosis: results from the cluster-randomized controlled GET UP PIANO Trial in a catchment area of 10 million inhabitants publication-title: Schizophr Bull doi: 10.1093/schbul/sbv058 – volume: 17 start-page: 47 year: 1995 ident: key 20180406155404_CIT0027 article-title: Anterior hippocampal volume reductions predict frontal lobe dysfunction in first episode schizophrenia publication-title: Schizophr Res doi: 10.1016/0920-9964(95)00028-K – volume: 58 start-page: 85 year: 2005 ident: key 20180406155404_CIT0042 article-title: Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2005.03.031 – volume: 65 start-page: 1017 year: 2008 ident: key 20180406155404_CIT0050 article-title: Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder publication-title: Arch Gen Psychiatry doi: 10.1001/archpsyc.65.9.1017 – volume: 202 start-page: 50 year: 2013 ident: key 20180406155404_CIT0010 article-title: Schizophrenia severity, social functioning and hippocampal neuroanatomy: three-dimensional mapping study publication-title: Br J Psychiatry doi: 10.1192/bjp.bp.111.105700 – volume: 68 start-page: 41 year: 2010 ident: key 20180406155404_CIT0054 article-title: Cortical thickness and subcortical volumes in schizophrenia and bipolar disorder publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2010.03.036 – volume: 37 start-page: 73 year: 2011 ident: key 20180406155404_CIT0053 article-title: Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group publication-title: Schizophr Bull doi: 10.1093/schbul/sbp034 – volume: 27 start-page: 351 year: 2007 ident: key 20180406155404_CIT0020 article-title: Hippocampal CA1 pyramidal cell size is reduced in bipolar disorder publication-title: Cell Mol Neurobiol doi: 10.1007/s10571-006-9128-7 – volume: 14 start-page: 393 year: 2004 ident: key 20180406155404_CIT0012 article-title: Stress and hippocampal abnormalities in psychiatric disorders publication-title: Eur Neuropsychopharmacol doi: 10.1016/j.euroneuro.2003.12.005 – volume: 6 start-page: 261 year: 2014 ident: key 20180406155404_CIT0036 article-title: A critical appraisal of the hippocampal subfield segmentation package in FreeSurfer publication-title: Front Aging Neurosci doi: 10.3389/fnagi.2014.00261 – volume: 68 start-page: 340 year: 2011 ident: key 20180406155404_CIT0019 article-title: Hippocampal interneurons in bipolar disorder publication-title: Arch Gen Psychiatry doi: 10.1001/archgenpsychiatry.2010.175 – volume: 19 start-page: 549 year: 2009 ident: key 20180406155404_CIT0028 article-title: Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI publication-title: Hippocampus doi: 10.1002/hipo.20615 – volume: 57 start-page: 633 year: 2005 ident: key 20180406155404_CIT0052 article-title: Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2004.12.009 – volume: 77 start-page: 581 year: 2015 ident: key 20180406155404_CIT0013 article-title: In vivo hippocampal subfield volumes in schizophrenia and bipolar disorder publication-title: Biol Psychiatry doi: 10.1016/j.biopsych.2014.06.020 – volume: 22 start-page: 142 year: 2017 ident: key 20180406155404_CIT0015 article-title: Progression from selective to general involvement of hippocampal subfields in schizophrenia publication-title: Mol Psychiatry doi: 10.1038/mp.2016.4 – volume: 35 start-page: 482 year: 2009 ident: key 20180406155404_CIT0057 article-title: Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or “schizoaffective”) psychoses publication-title: Schizophr Bull doi: 10.1093/schbul/sbp020 – reference: 15698673 - Psychiatry Res. 2005 Jan 30;133(1):13-21 – reference: 25936807 - Neuroimage. 2015 Jul 15;115:117-37 – reference: 25995057 - Schizophr Bull. 2015 Sep;41(5):1192-203 – reference: 17765709 - Prog Brain Res. 2007;163:3-22 – reference: 15744031 - J Med Genet. 2005 Mar;42(3):193-204 – reference: 27095442 - Epidemiol Psychiatr Sci. 2016 Aug;25(4):312-6 – reference: 19405131 - Hippocampus. 2009 Jun;19(6):549-57 – reference: 11832223 - Neuron. 2002 Jan 31;33(3):341-55 – reference: 25127742 - Biol Psychiatry. 2015 Mar 15;77(6):581-8 – reference: 28079061 - Neuropsychopharmacology. 2017 May;42(6):1361-1370 – reference: 20810471 - Am J Psychiatry. 2010 Oct;167(10):1178-93 – reference: 23284150 - Br J Psychiatry. 2013 Jan;202(1):50-5 – reference: 19443616 - Schizophr Bull. 2011 Jan;37(1):73-83 – reference: 21135314 - Arch Gen Psychiatry. 2011 Apr;68(4):340-50 – reference: 22647399 - Trials. 2012 May 30;13:73 – reference: 18762588 - Arch Gen Psychiatry. 2008 Sep;65(9):1017-32 – reference: 25477768 - Conf Proc (Midwest Symp Circuits Syst). 2014 Aug;2014:813-816 – reference: 9167509 - Am J Psychiatry. 1997 Jun;154(6):812-8 – reference: 23597720 - Trends Cogn Sci. 2013 May;17(5):230-40 – reference: 15336301 - Eur Neuropsychopharmacol. 2004 Oct;14(5):393-405 – reference: 11126396 - Mol Psychiatry. 2000 Nov;5(6):654-63, 571 – reference: 18391185 - Learn Mem. 2008 Apr 03;15(4):244-51 – reference: 22692142 - Transl Psychiatry. 2012 Jun 12;2:e127 – reference: 23637625 - PLoS Genet. 2013 Apr;9(4):e1003455 – reference: 24828364 - JAMA Psychiatry. 2014 Jul 1;71(7):769-77 – reference: 15132429 - Hippocampus. 2004;14(3):301-10 – reference: 25842202 - Biol Psychiatry. 2016 Feb 15;79(4):282-92 – reference: 26903271 - Mol Psychiatry. 2017 Jan;22(1):142-152 – reference: 19502360 - Hum Mol Genet. 2009 Sep 1;18(17):3286-97 – reference: 25309437 - Front Aging Neurosci. 2014 Sep 25;6:261 – reference: 20929969 - Schizophr Bull. 2010 Nov;36(6):1061-2 – reference: 15263907 - Mol Psychiatry. 2005 Jan;10(1):40-68; image 5 – reference: 19329560 - Schizophr Bull. 2009 May;35(3):482-90 – reference: 16038679 - Biol Psychiatry. 2005 Jul 15;58(2):85-96 – reference: 25959503 - Hum Brain Mapp. 2015 Aug;36(8):3020-37 – reference: 11732707 - Hippocampus. 2001;11(5):543-50 – reference: 18957228 - Neuron. 2008 Oct 23;60(2):378-89 – reference: 19150704 - Lancet. 2009 Jan 17;373(9659):234-9 – reference: 15038994 - Biol Psychiatry. 2004 Apr 1;55(7):668-75 – reference: 23388407 - Brain. 2013 Mar;136(Pt 3):804-14 – reference: 16040709 - Science. 2005 Jul 22;309(5734):619-23 – reference: 11875571 - Nature. 2002 Feb 28;415(6875):1030-4 – reference: 10025437 - Arch Gen Psychiatry. 1999 Feb;56(2):133-41 – reference: 23583108 - Neuron. 2013 Apr 10;78(1):81-93 – reference: 20085668 - Psychol Med. 2010 Sep;40(9):1409-22 – reference: 8541249 - Schizophr Res. 1995 Sep;17(1):47-58 – reference: 15219675 - Neuroscience. 2004;127(1):125-36 – reference: 9646890 - Biol Psychiatry. 1998 Jul 15;44(2):88-97 – reference: 28115740 - Mol Psychiatry. 2017 Sep;22(9):1352-1358 – reference: 17570643 - Schizophr Res. 2007 Aug;94(1-3):288-92 – reference: 20609836 - Biol Psychiatry. 2010 Jul 1;68(1):41-50 – reference: 9931268 - Neuroimage. 1999 Feb;9(2):179-94 – reference: 15780850 - Biol Psychiatry. 2005 Mar 15;57(6):633-9 – reference: 17235693 - Cell Mol Neurobiol. 2007 May;27(3):351-8 – reference: 17961984 - Schizophr Res. 2008 Jan;98(1-3):105-10 – reference: 11005874 - Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11032-7
SSID	ssj0014962
Score	2.4849086
Snippet	Abstract Background Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved... Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the... Background Hippocampal abnormalities have been largely reported in patients with schizophrenia and bipolar disorder, and are considered to be involved in the...
SourceID	pubmedcentral proquest pubmed crossref oup
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source Publisher
StartPage	552
SubjectTerms	Adult Bipolar Disorder - diagnostic imaging Bipolar Disorder - pathology CA1 Region, Hippocampal - diagnostic imaging CA1 Region, Hippocampal - pathology CA3 Region, Hippocampal - diagnostic imaging CA3 Region, Hippocampal - pathology Female Hippocampus - diagnostic imaging Hippocampus - pathology Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Middle Aged Psychosis Psychotic Disorders - diagnostic imaging Psychotic Disorders - pathology Regular Schizophrenia - diagnostic imaging Schizophrenia - pathology Schizotypal Personality Disorder - diagnostic imaging Schizotypal Personality Disorder - pathology Young Adult
Title	Hippocampal Subfield Volumes in Patients With First-Episode Psychosis
URI	https://www.ncbi.nlm.nih.gov/pubmed/29897598 https://www.proquest.com/docview/3192269762 https://www.proquest.com/docview/2054933505 https://pubmed.ncbi.nlm.nih.gov/PMC5890476
Volume	44
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3da9swEBf9eNnL2Oi6peuKBmVPE4mis2w_jNGWZKGwUEa75c1YOpkaguPWCezP38lfSwrrnn3I5nQfv7NOv2PsXBvC3SGm5OKBExDEmYhNrIQDF2ZSW0ry_oLz97me3cH1IljssXl3F8a3VXYxsQ7UuLL-H_mQTIWQAiXP8dfyQfipUf50tRuhkbajFfBLTTG2zw4pJEdk94eXk_nNj_5cAeJ6xOgoiLSgAh5a1k0q64dUTJrNcliZ39LPmtzKUjs337YA6NM-yq3ENH3FXraIkl80JvCa7bniiE1meVlSmiJnX3IKDnWjGv9Zh6KK5wW_afhUK_4rX9_zaU4gUEzKvFqh401QrPLqDbubTm6vZqKdmCAslVlroY0NDWbWKAMjQAwBFEq0yiejQIXKUAUB0oKUmRujQq10hGmGVqao7Vgds4NiVbh3jEc6BowQpQGAzIEJEKni1CaznsIvHbDPnYYS29KJ-6kWy6Q51lZJo9CkUeiAferFy4ZH41-CH0nd_5M57TYjaV2uSv4aCC3RPyZn8ScgaeFWmyoZE0CNlSLUN2Bvm73r3-Sp6MMgpsXDnV3tBTwR9-6TIr-vCbmDKB5BqE-e_6z37AWhrahu-9Gn7GD9uHEfCNGszVlrpmds_9tC_gHzC_rg
linkProvider	ProQuest
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaq7QEuCMRroQUjASes3cSOHR8qxGNXW9quKtRCbyH2OGqkVTY0uwL-HL-NcV7sIgGnnjNyohl75puM5xtCnkuDuFtBikc8ckxEOmPaaM6ccCoLpMUg7xucT-Zydi4-XEQXO-Rn1wvjr1V2PrF21LC0_h_5CLcKIgUMnuHr8ivzU6N8dbUboZG2oxXgoKYYaxs7jtyPb5jCVQeH79HeL8JwOjl7N2PtlAFmMTVZMWmsMpBZw40YCwAlBIcALPcOPOKKG0TdIrAiCDIXAgfJZQxpBjZIQVpPfIAhYFf4DtcB2X07mZ9-7OsYQtcjTcdRLJnCSNiyfI41H2HyataLUWW-B3625UZU3Oq02wC8f97b3AiE09vkVotg6Ztmy90hO664SyazvCwxLKJzWVB0RvXFOPqpdn0VzQt62vC3VvRzvrqk0xxBJ5uUebUERxsnXOXVPXJ-Lbq7TwbFsnAPCY2lFhADBEYIkTlhIgDMcKXJrKcMTIfkVaehxLb05X6KxiJpyug8aRSaNAodkpe9eNnwdvxN8Bmq-38ye50xkvaIV8nvDYlL9I_xcPqKS1q45bpKQgTEmnNEmUPyoLFd_yZPfa8ijYurLav2Ap74e_tJkV_WBOBRrMdCyUf__qyn5Mbs7OQ4OT6cHz0mNxHpxfWVI7lHBqurtdtHNLUyT9otS8mX6z4lvwABZTeR
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hippocampal+Subfield+Volumes+in+Patients+With+First-Episode+Psychosis&rft.jtitle=Schizophrenia+bulletin&rft.au=Baglivo%2C+Valentina&rft.au=Cao%2C+Bo&rft.au=Mwangi%2C+Benson&rft.au=Bellani%2C+Marcella&rft.date=2018-04-06&rft.pub=Oxford+University+Press&rft.issn=0586-7614&rft.eissn=1745-1701&rft.volume=44&rft.issue=3&rft.spage=552&rft.epage=559&rft_id=info:doi/10.1093%2Fschbul%2Fsbx108&rft_id=info%3Apmid%2F29897598&rft.externalDocID=PMC5890476
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0586-7614&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0586-7614&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0586-7614&client=summon