The Role of PKM2 in the Regulation of Mitochondrial Function: Focus on Mitochondrial Metabolism, Oxidative Stress, Dynamic, and Apoptosis. PKM2 in Mitochondrial Function

• Published in: Oxidative medicine and cellular longevity Vol. 2022; no. 1; p. 7702681
• Main Authors: Gao, Jing, Zhao, Yuwei, Li, Tao, Gan, Xueqi, Yu, Haiyang
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2022; John Wiley & Sons, Inc
• Subjects: Apoptosis; Autoimmune diseases; Cancer; Glucose; Glycolysis - physiology; Kinases; Metabolism; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Oxidative Stress; Phosphorylation; Physiology; Protein Isoforms - metabolism; Proteins; Pyruvate Kinase - metabolism; Reactive oxygen species; Review

The M2 isoform of pyruvate kinase (PKM2) is one isoform of pyruvate kinase (PK). PKM2 is expressed at high levels during embryonic development and tumor progression and is subject to complex allosteric regulation. PKM2 is a special glycolytic enzyme that regulates the final step of glycolysis; the r...