Axon morphology and intrinsic cellular properties determine repetitive transcranial magnetic stimulation threshold for plasticity

• Published in: Frontiers in cellular neuroscience Vol. 18; p. 1374555
• Main Authors: Galanis, Christos, Neuhaus, Lena, Hananeia, Nicholas, Turi, Zsolt, Jedlicka, Peter, Vlachos, Andreas
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 03.04.2024; Frontiers Media S.A
• Subjects: Animal welfare; axons; Brain; Cell activation; Cellular Neuroscience; Computational neuroscience; Electric fields; excitation; Glucose; Hippocampus; inhibition; Magnetic fields; Mathematical models; Molecular modelling; Morphology; Neural networks; Neuroplasticity; Penicillin; Pyramidal cells; Standardization; Structure-function relationships; Sucrose; Synaptic plasticity; Synaptic strength; Transcranial magnetic stimulation; whole-cell patch-clamp recordings; Switzerland; organotypic tissue cultures; axons; morphology; excitation; whole-cell patch-clamp recordings; inhibition; synaptic plasticity

Repetitive transcranial magnetic stimulation (rTMS) is a widely used therapeutic tool in neurology and psychiatry, but its cellular and molecular mechanisms are not fully understood. Standardizing stimulus parameters, specifically electric field strength, is crucial in experimental and clinical sett...