The liver as the site of C-reactive protein formation

• Published in: The Journal of experimental medicine Vol. 123; no. 2; pp. 365 - 378
• Main Authors: Hurlimann, J, Thorbecke, G J, Hochwald, G M
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 01.02.1966
• Subjects: Amino Acids; Animals; Autoradiography; C-Reactive Protein - isolation & purification; Carbon Isotopes - metabolism; Croton Oil; Endotoxins; Haplorhini; Humans; Immunoelectrophoresis; In Vitro Techniques; Liver - metabolism; Rabbits; Streptococcus pneumoniae; Turpentine; Typhoid-Paratyphoid Vaccines

The site of formation of C-reactive protein (CxRP, CRP) has been studied with tissues from rabbits, monkeys, and human beings. Rabbits and monkeys were stimulated to produce the acute phase protein by injection of turpentine, croton oil, endotoxin, paratyphoid-typhoid vaccine, or pneumococci. C(14)-...