The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation

• Published in: Sleep (New York, N.Y.) Vol. 26; no. 2; pp. 117 - 126
• Main Authors: Van Dongen, Hans P A., Maislin, Greg, Mullington, Janet M., Dinges, David F.
• Format: Journal Article
• Language: English
• Published: Legacy CDMS American Academy of Sleep Medicine 15.03.2003
• Subjects: Activity levels. Psychomotricity; Adult; Behavioral Sciences; Biological and medical sciences; Chronic Disease; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Electroencephalography; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; Models, Biological; Neuropsychological Tests; Polysomnography; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Random Allocation; Severity of Illness Index; Sleep Deprivation - complications; Sleep Deprivation - diagnosis; Sleep, REM - physiology; Time Factors; Vigilance. Attention. Sleep; Wakefulness - physiology; Support, U.s. Gov't, Non-P.h.s; Human; Support, U.s. Gov't, P.h.s; Non-Nasa Center; Wakefulness/physiology; Male; Electroencephalography; Random Allocation; Sleep Deprivation/complications/diagnosis; Polysomnography; Neuropsychological Tests; Cognition Disorders/diagnosis/etiology; Time Factors; Models, Biological; Nasa Discipline Regulatory Physiology; Female; Adult; Sleep, Rem/physiology; Severity Of Illness Index; Chronic Disease; Vigilance; Deprivation; Delta rhythm; Neuropsychological test; Cognition; Experimental study; Slow wave sleep; Dose activity relation; Progressive; Sleep; Investigation method; Arousal; Problem solving; NASA Discipline Regulatory Physiology; Non-NASA Center

OBJECTIVES: To inform the debate over whether human sleep can be chronically reduced without consequences, we conducted a dose-response chronic sleep restriction experiment in which waking neurobehavioral and sleep physiological functions were monitored and compared to those for total sleep deprivat...