Genetic Association of the Antiviral Restriction Factor TRIM5α with Human Immunodeficiency Virus Type 1 Infection

Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from...

Full description

Saved in:
Bibliographic Details
Published inJournal of Virology Vol. 80; no. 5; pp. 2463 - 2471
Main Authors Speelmon, Emily C., Livingston-Rosanoff, Devon, Li, Shuying Sue, Vu, Quyen, Bui, John, Geraghty, Daniel E., Zhao, Lue Ping, McElrath, M. Juliana
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.03.2006
Subjects
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genetic Diversity and Evolution
Human immunodeficiency virus 1
Human viral diseases
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Retrovirus
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
Immunopathology
Microbiology
HIV-1 virus
Retroviridae
AIDS
Immune deficiency
Lentivirus
Virology
Infection
Virus
Viral disease
Antiviral
Human immunodeficiency virus
Online AccessGet full text

Cover

Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList The innate antiviral factor TRIM5 alpha restricts the replication of some retroviruses through its interaction with the viral capsid protein, leading to abortive infection. While overexpression of human TRIM5 alpha results in modest restriction of human immunodeficiency virus type 1 (HIV-1), this inhibition is insufficient to block productive infection of human cells. We hypothesized that polymorphisms within TRIM5 may result in increased restriction of HIV-1 infection. We sequenced the TRIM5 gene (excluding exon 5) and the 4.8-kb 5' putative regulatory region in genomic DNA from 110 HIV-1-infected subjects and 96 exposed seronegative persons, along with targeted gene sequencing in a further 30 HIV-1-infected individuals. Forty-eight single nucleotide polymorphisms (SNPs), including 20 with allele frequencies of >1.0%, were identified. Among these were two synonymous and eight nonsynonymous coding polymorphisms. We observed no association between TRIM5 polymorphism in HIV-1-infected subjects and their set-point viral load after acute infection, although one TRIM5 haplotype was weakly associated with more rapid CD4 super(+) T-cell loss. Importantly, a TRIM5 haplotype containing the nonsynonymous SNP R136Q showed increased frequency among HIV-1-infected subjects relative to exposed seronegative persons, with an odds ratio of 5.49 (95% confidence interval = 1.83 to 16.45; P = 0.002). Nonetheless, we observed no effect of individual TRIM5 alpha nonsynonymous mutations on the in vitro HIV-1 susceptibility of CD4 super(+) T cells. Therefore, any effect of TRIM5 alpha polymorphism on HIV-1 infection in primary lymphocytes may depend on combinations of SNPs or on DNA sequences in linkage disequilibrium with the TRIM5 alpha coding sequence.
The innate antiviral factor TRIM5α restricts the replication of some retroviruses through its interaction with the viral capsid protein, leading to abortive infection. While overexpression of human TRIM5α results in modest restriction of human immunodeficiency virus type 1 (HIV-1), this inhibition is insufficient to block productive infection of human cells. We hypothesized that polymorphisms within TRIM5 may result in increased restriction of HIV-1 infection. We sequenced the TRIM5 gene (excluding exon 5) and the 4.8-kb 5′ putative regulatory region in genomic DNA from 110 HIV-1-infected subjects and 96 exposed seronegative persons, along with targeted gene sequencing in a further 30 HIV-1-infected individuals. Forty-eight single nucleotide polymorphisms (SNPs), including 20 with allele frequencies of >1.0%, were identified. Among these were two synonymous and eight nonsynonymous coding polymorphisms. We observed no association between TRIM5 polymorphism in HIV-1-infected subjects and their set-point viral load after acute infection, although one TRIM5 haplotype was weakly associated with more rapid CD4 + T-cell loss. Importantly, a TRIM5 haplotype containing the nonsynonymous SNP R136Q showed increased frequency among HIV-1-infected subjects relative to exposed seronegative persons, with an odds ratio of 5.49 (95% confidence interval = 1.83 to 16.45; P = 0.002). Nonetheless, we observed no effect of individual TRIM5α nonsynonymous mutations on the in vitro HIV-1 susceptibility of CD4 + T cells. Therefore, any effect of TRIM5α polymorphism on HIV-1 infection in primary lymphocytes may depend on combinations of SNPs or on DNA sequences in linkage disequilibrium with the TRIM5α coding sequence.
Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
Author John Bui
M. Juliana McElrath
Shuying Sue Li
Quyen Vu
Devon Livingston-Rosanoff
Emily C. Speelmon
Daniel E. Geraghty
Lue Ping Zhao
AuthorAffiliation Medical Scientist Training Program, 1 Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, 2 Clinical Research, 3 Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington, 4 Departments of Medicine, 5 Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 6
AuthorAffiliation_xml – name: Medical Scientist Training Program, 1 Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, 2 Clinical Research, 3 Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington, 4 Departments of Medicine, 5 Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 6
Author_xml – sequence: 1
  givenname: Emily C.
  surname: Speelmon
  fullname: Speelmon, Emily C.
  organization: Medical Scientist Training Program, Molecular and Cellular Biology Program, University of Washington, Seattle, Washington, Clinical Research
– sequence: 2
  givenname: Devon
  surname: Livingston-Rosanoff
  fullname: Livingston-Rosanoff, Devon
  organization: Clinical Research
– sequence: 3
  givenname: Shuying Sue
  surname: Li
  fullname: Li, Shuying Sue
  organization: Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington
– sequence: 4
  givenname: Quyen
  surname: Vu
  fullname: Vu, Quyen
  organization: Clinical Research
– sequence: 5
  givenname: John
  surname: Bui
  fullname: Bui, John
  organization: Clinical Research
– sequence: 6
  givenname: Daniel E.
  surname: Geraghty
  fullname: Geraghty, Daniel E.
  organization: Clinical Research
– sequence: 7
  givenname: Lue Ping
  surname: Zhao
  fullname: Zhao, Lue Ping
  organization: Public Health Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, Washington
– sequence: 8
  givenname: M. Juliana
  surname: McElrath
  fullname: McElrath, M. Juliana
  organization: Clinical Research, Departments of Medicine, Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17511706$$DView record in Pascal Francis
BookMark eNqNkd1uFCEYhompsdvqNYgHejYjzMAAB5psGtuOqTFp1sYzwjLQpZmBFZht9rK8Ea_J2Z_Y6JFHHHzP-8LHcwZOfPAGgNcYlRhX_P3nu7bkqKRlRZq6qAjDZYVQ8wzMMBK8oBSTEzBDqKoKWvPvp-AspQeEMCENeQFOcUMYwbSegXhlvMlOw3lKQTuVXfAwWJhXBs59dhsXVQ9vTcrR6f3wUukcIlzctl_or5_w0eUVvB4H5WE7DKMPnbFOO-P1Ft65OCa42K4NxLD11uwbXoLnVvXJvDqe5-Db5afFxXVx8_WqvZjfFJoQngsqkDIIaWq0rRgTii0Z1Z1SqBNGI2FrzbhW1DaCcoHVsiO8Q5VlXFnSMVWfg4-H3vW4HEynjc_TLnId3aDiVgbl5N8T71byPmwkrgWtGzEVvDsWxPBjnL5ADi5p0_fKmzAmiQWva07pBL49gipp1duovHbpz02YUYwZaiaOHTgdQ0rR2CcEyZ1XOXmVHEkqd17lzqvceZ2SH_5Japf3sqaXu_4_8m8O-ZW7Xz26aKRKg3zYuCe6_g1_lrjW
CitedBy_id crossref_primary_10_1016_j_micinf_2010_05_004
crossref_primary_10_1016_j_micpath_2021_105326
crossref_primary_10_1186_1742_4690_3_54
crossref_primary_10_3389_fimmu_2017_01616
crossref_primary_10_1371_journal_ppat_1000738
crossref_primary_10_1016_j_vaccine_2014_01_057
crossref_primary_10_3389_fgene_2022_861355
crossref_primary_10_1128_JVI_03603_13
crossref_primary_10_1097_QAD_0b013e328331567a
crossref_primary_10_2217_fvl_11_134
crossref_primary_10_3389_fimmu_2018_02876
crossref_primary_10_1371_journal_ppat_1003577
crossref_primary_10_1097_QAI_0b013e318205a59b
crossref_primary_10_1371_journal_pone_0002747
crossref_primary_10_1089_aid_2012_0369
crossref_primary_10_1007_s00251_007_0217_7
crossref_primary_10_1371_journal_ppat_0040018
crossref_primary_10_1007_s00251_009_0358_y
crossref_primary_10_1016_j_tube_2011_08_004
crossref_primary_10_1007_s12026_016_8810_1
crossref_primary_10_1186_1475_2875_13_236
crossref_primary_10_1016_j_smim_2013_04_007
crossref_primary_10_1073_pnas_0601373103
crossref_primary_10_1016_j_virol_2006_06_031
crossref_primary_10_3390_v13020320
crossref_primary_10_1097_QAD_0000000000000812
crossref_primary_10_1111_j_1365_2796_2008_02041_x
crossref_primary_10_1128_JVI_02978_14
crossref_primary_10_1007_s00439_009_0763_1
crossref_primary_10_1038_srep45214
crossref_primary_10_1089_aid_2012_0039
crossref_primary_10_1099_vir_0_050252_0
crossref_primary_10_1016_S2222_1808_16_61145_3
crossref_primary_10_1371_journal_pbio_1000462
crossref_primary_10_1146_annurev_genet_120116_023425
crossref_primary_10_1097_COH_0b013e3282f7cda4
crossref_primary_10_1155_2020_6702169
crossref_primary_10_1371_journal_ppat_1009017
crossref_primary_10_1073_pnas_0605838103
crossref_primary_10_2217_17469600_2_2_167
crossref_primary_10_1007_s11908_007_0013_4
crossref_primary_10_1007_s00439_010_0884_6
crossref_primary_10_1089_aid_2010_0367
crossref_primary_10_1371_journal_pone_0029454
crossref_primary_10_1086_590431
crossref_primary_10_1128_JVI_00688_06
crossref_primary_10_1016_j_tim_2008_09_003
crossref_primary_10_1097_QAD_0b013e32835ab1f2
crossref_primary_10_1097_QAD_0b013e328330b489
crossref_primary_10_1128_JVI_01828_07
crossref_primary_10_1186_1742_4690_10_85
crossref_primary_10_1002_jgm_3004
crossref_primary_10_1002_jmv_26423
crossref_primary_10_1097_QAD_0b013e3282effa87
crossref_primary_10_4103_ijmm_IJMM_20_109
crossref_primary_10_1097_QAD_0b013e32831fb540
crossref_primary_10_1186_1742_4690_3_81
crossref_primary_10_2217_17469600_1_4_399
crossref_primary_10_1097_QAD_0b013e32833b5256
crossref_primary_10_1586_eci_13_16
crossref_primary_10_1371_journal_pone_0084917
crossref_primary_10_1128_JVI_01810_10
crossref_primary_10_1089_aid_2015_0067
crossref_primary_10_1016_j_tig_2010_01_002
crossref_primary_10_1089_aid_2007_0256
crossref_primary_10_1128_JVI_01313_13
crossref_primary_10_1016_S0929_6646_11_60053_3
crossref_primary_10_1128_JVI_00854_11
crossref_primary_10_1016_j_virol_2009_05_038
crossref_primary_10_1016_j_virol_2013_03_021
crossref_primary_10_1002_rmv_637
crossref_primary_10_3390_v6010243
Cites_doi 10.1038/nm0195-59
10.1128/JVI.78.11.5670-5678.2004
10.1073/pnas.172384599
10.1016/S0092-8674(00)80110-5
10.1128/JVI.79.12.7883-7888.2005
10.1016/S0140-6736(97)09185-X
10.1128/JVI.79.14.8969-8978.2005
10.1093/emboj/20.9.2140
10.1128/JVI.73.12.10020-10028.1999
10.7326/0003-4819-128-8-199804150-00001
10.7326/0003-4819-125-4-199608150-00001
10.1086/375140
10.1073/pnas.212400099
10.1038/nature01709
10.4269/ajtmh.1999.61.420
10.1073/pnas.0402361101
10.1006/meth.1997.0487
10.1097/00002030-200307250-00002
10.1038/ng934
10.1073/pnas.0409853102
10.1128/JVI.78.11.6005-6012.2004
10.1073/pnas.200286297
10.1101/gr.8.3.195
10.1038/nature02343
10.1128/JVI.79.7.3930-3937.2005
10.1016/j.cub.2004.12.042
10.1101/gr.8.3.186
10.1128/JVI.79.5.3139-3145.2005
10.1128/JVI.75.17.7944-7955.2001
10.1101/gr.8.3.175
10.1086/314632
10.1128/jvi.71.6.4284-4295.1997
10.1128/JVI.74.21.10074-10080.2000
10.1073/pnas.96.3.1030
10.1086/314556
10.1128/JVI.78.11.6073-6076.2004
10.4049/jimmunol.162.11.6942
10.1093/emboj/cdg042
10.1073/pnas.162299499
10.1073/pnas.0402474101
10.1038/nature00939
10.1073/pnas.0402876101
10.1093/biostatistics/4.4.513
10.1038/nm946
10.1086/343811
10.1056/NEJM199501263320401
10.1128/jvi.64.10.4735-4742.1990
10.1073/pnas.0403364101
10.1016/S0140-6736(95)12269-2
10.1128/JVI.78.20.11070-11076.2004
ContentType Journal Article
Copyright 2006 INIST-CNRS
Copyright © 2006, American Society for Microbiology 2006
Copyright_xml – notice: 2006 INIST-CNRS
– notice: Copyright © 2006, American Society for Microbiology 2006
DBID AAYXX
CITATION
IQODW
7T5
7T7
7U9
8FD
C1K
FR3
H94
P64
RC3
5PM
DOI 10.1128/JVI.80.5.2463-2471.2006
DatabaseName CrossRef
Pascal-Francis
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
Genetics Abstracts
Virology and AIDS Abstracts
Technology Research Database
AIDS and Cancer Research Abstracts
Immunology Abstracts
Engineering Research Database
Industrial and Applied Microbiology Abstracts (Microbiology A)
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
DatabaseTitleList Genetics Abstracts
CrossRef
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5514
EndPage 2471
ExternalDocumentID PMC1395369
17511706
10_1128_JVI_80_5_2463_2471_2006
jvi_80_5_2463
GroupedDBID ---
-~X
.55
.GJ
0R~
18M
29L
2WC
39C
3O-
4.4
41~
53G
5GY
5RE
5VS
6TJ
85S
AAFWJ
AAGFI
AAYJJ
AAYXX
ABPPZ
ACGFO
ACNCT
ADBBV
ADXHL
AENEX
AFFNX
AGVNZ
AI.
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BTFSW
C1A
CITATION
CS3
D0S
DIK
E3Z
EBS
EJD
F5P
FRP
GX1
H13
HYE
HZ~
IH2
KQ8
MVM
N9A
O9-
OHT
OK1
P2P
RHI
RNS
RPM
RSF
TR2
UPT
VH1
W2D
W8F
WH7
WOQ
X7M
Y6R
YQT
ZGI
ZXP
~02
~KM
IQODW
7T5
7T7
7U9
8FD
C1K
FR3
H94
P64
RC3
5PM
ID FETCH-LOGICAL-c448t-590ae00c5ecf2779a7b75cdaa0d9ec09f3c78ca5f695891abd48d02f78af4d7a3
ISSN 0022-538X
IngestDate Thu Aug 21 18:28:14 EDT 2025
Thu Jul 10 22:15:59 EDT 2025
Mon Jul 21 09:15:41 EDT 2025
Tue Jul 01 00:56:59 EDT 2025
Thu Apr 24 22:53:14 EDT 2025
Wed May 18 15:32:09 EDT 2016
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Immunopathology
Microbiology
HIV-1 virus
Retroviridae
AIDS
Immune deficiency
Lentivirus
Virology
Infection
Virus
Viral disease
Antiviral
Human immunodeficiency virus
Language English
License CC BY 4.0
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c448t-590ae00c5ecf2779a7b75cdaa0d9ec09f3c78ca5f695891abd48d02f78af4d7a3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Corresponding author. Mailing address: Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, D3-100, Seattle, WA 98109-1024. Phone: (206) 667-6704. Fax: (206) 667-4411. E-mail: jmcelrat@fhcrc.org.
OpenAccessLink https://jvi.asm.org/content/jvi/80/5/2463.full.pdf
PMID 16474153
PQID 19833855
PQPubID 23462
PageCount 9
ParticipantIDs pascalfrancis_primary_17511706
proquest_miscellaneous_19833855
highwire_asm_jvi_80_5_2463
crossref_primary_10_1128_JVI_80_5_2463_2471_2006
crossref_citationtrail_10_1128_JVI_80_5_2463_2471_2006
pubmedcentral_primary_oai_pubmedcentral_nih_gov_1395369
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2006-03-01
PublicationDateYYYYMMDD 2006-03-01
PublicationDate_xml – month: 03
  year: 2006
  text: 2006-03-01
  day: 01
PublicationDecade 2000
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
PublicationTitle Journal of Virology
PublicationYear 2006
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References e_1_3_2_26_2
e_1_3_2_28_2
e_1_3_2_43_2
e_1_3_2_22_2
e_1_3_2_45_2
(e_1_3_2_39_2) 2000; 132
e_1_3_2_24_2
e_1_3_2_47_2
(e_1_3_2_14_2) 2000; 2
e_1_3_2_9_2
e_1_3_2_16_2
e_1_3_2_37_2
e_1_3_2_7_2
e_1_3_2_18_2
(e_1_3_2_41_2) 2005; 16
e_1_3_2_54_2
e_1_3_2_10_2
e_1_3_2_31_2
e_1_3_2_52_2
e_1_3_2_5_2
e_1_3_2_12_2
e_1_3_2_33_2
e_1_3_2_3_2
e_1_3_2_35_2
e_1_3_2_50_2
e_1_3_2_27_2
e_1_3_2_48_2
(e_1_3_2_20_2) 1999; 162
e_1_3_2_29_2
e_1_3_2_40_2
e_1_3_2_21_2
e_1_3_2_42_2
e_1_3_2_23_2
e_1_3_2_44_2
e_1_3_2_25_2
e_1_3_2_46_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_17_2
e_1_3_2_6_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_53_2
e_1_3_2_32_2
e_1_3_2_51_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_4_2
e_1_3_2_13_2
e_1_3_2_36_2
e_1_3_2_55_2
e_1_3_2_2_2
(e_1_3_2_49_2) 1992
References_xml – ident: e_1_3_2_38_2
  doi: 10.1038/nm0195-59
– ident: e_1_3_2_51_2
  doi: 10.1128/JVI.78.11.5670-5678.2004
– ident: e_1_3_2_5_2
  doi: 10.1073/pnas.172384599
– ident: e_1_3_2_24_2
  doi: 10.1016/S0092-8674(00)80110-5
– ident: e_1_3_2_4_2
  doi: 10.1128/JVI.79.12.7883-7888.2005
– ident: e_1_3_2_36_2
  doi: 10.1016/S0140-6736(97)09185-X
– volume: 132
  start-page: 365
  year: 2000
  ident: e_1_3_2_39_2
  publication-title: Methods Mol. Biol.
– ident: e_1_3_2_34_2
  doi: 10.1128/JVI.79.14.8969-8978.2005
– ident: e_1_3_2_37_2
  doi: 10.1093/emboj/20.9.2140
– ident: e_1_3_2_21_2
  doi: 10.1128/JVI.73.12.10020-10028.1999
– ident: e_1_3_2_43_2
  doi: 10.7326/0003-4819-128-8-199804150-00001
– ident: e_1_3_2_42_2
  doi: 10.7326/0003-4819-125-4-199608150-00001
– ident: e_1_3_2_54_2
  doi: 10.1086/375140
– ident: e_1_3_2_30_2
  doi: 10.1073/pnas.212400099
– ident: e_1_3_2_26_2
  doi: 10.1038/nature01709
– ident: e_1_3_2_12_2
  doi: 10.4269/ajtmh.1999.61.420
– ident: e_1_3_2_19_2
  doi: 10.1073/pnas.0402361101
– ident: e_1_3_2_3_2
  doi: 10.1006/meth.1997.0487
– ident: e_1_3_2_29_2
  doi: 10.1097/00002030-200307250-00002
– ident: e_1_3_2_28_2
  doi: 10.1038/ng934
– ident: e_1_3_2_40_2
  doi: 10.1073/pnas.0409853102
– ident: e_1_3_2_18_2
  doi: 10.1128/JVI.78.11.6005-6012.2004
– ident: e_1_3_2_50_2
  doi: 10.1073/pnas.200286297
– start-page: 7.22.1
  year: 1992
  ident: e_1_3_2_49_2
  publication-title: Current protocols in immunology
– ident: e_1_3_2_16_2
  doi: 10.1101/gr.8.3.195
– ident: e_1_3_2_47_2
  doi: 10.1038/nature02343
– volume: 2
  start-page: 532
  year: 2000
  ident: e_1_3_2_14_2
  publication-title: Rev. Immunogenet.
– ident: e_1_3_2_45_2
  doi: 10.1128/JVI.79.7.3930-3937.2005
– ident: e_1_3_2_53_2
  doi: 10.1016/j.cub.2004.12.042
– ident: e_1_3_2_10_2
  doi: 10.1101/gr.8.3.186
– ident: e_1_3_2_48_2
  doi: 10.1128/JVI.79.5.3139-3145.2005
– ident: e_1_3_2_31_2
  doi: 10.1128/JVI.75.17.7944-7955.2001
– ident: e_1_3_2_11_2
  doi: 10.1101/gr.8.3.175
– ident: e_1_3_2_15_2
  doi: 10.1086/314632
– ident: e_1_3_2_25_2
  doi: 10.1128/jvi.71.6.4284-4295.1997
– ident: e_1_3_2_32_2
  doi: 10.1128/JVI.74.21.10074-10080.2000
– ident: e_1_3_2_46_2
  doi: 10.1073/pnas.96.3.1030
– ident: e_1_3_2_6_2
  doi: 10.1086/314556
– ident: e_1_3_2_55_2
  doi: 10.1128/JVI.78.11.6073-6076.2004
– volume: 162
  start-page: 6942
  year: 1999
  ident: e_1_3_2_20_2
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.162.11.6942
– ident: e_1_3_2_17_2
  doi: 10.1093/emboj/cdg042
– ident: e_1_3_2_9_2
  doi: 10.1073/pnas.162299499
– ident: e_1_3_2_22_2
  doi: 10.1073/pnas.0402474101
– ident: e_1_3_2_44_2
  doi: 10.1038/nature00939
– ident: e_1_3_2_52_2
  doi: 10.1073/pnas.0402876101
– ident: e_1_3_2_23_2
  doi: 10.1093/biostatistics/4.4.513
– ident: e_1_3_2_27_2
  doi: 10.1038/nm946
– ident: e_1_3_2_33_2
  doi: 10.1086/343811
– volume: 16
  start-page: 95
  year: 2005
  ident: e_1_3_2_41_2
  publication-title: Curr. Biol.
– ident: e_1_3_2_8_2
  doi: 10.1056/NEJM199501263320401
– ident: e_1_3_2_7_2
  doi: 10.1128/jvi.64.10.4735-4742.1990
– ident: e_1_3_2_35_2
  doi: 10.1073/pnas.0403364101
– ident: e_1_3_2_13_2
  doi: 10.1016/S0140-6736(95)12269-2
– ident: e_1_3_2_2_2
  doi: 10.1128/JVI.78.20.11070-11076.2004
SSID ssj0014464
Score 2.188423
Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
The innate antiviral factor TRIM5α restricts the replication of some retroviruses through its interaction with the viral capsid protein, leading to abortive...
The innate antiviral factor TRIM5 alpha restricts the replication of some retroviruses through its interaction with the viral capsid protein, leading to...
SourceID pubmedcentral
proquest
pascalfrancis
crossref
highwire
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 2463
SubjectTerms Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genetic Diversity and Evolution
Human immunodeficiency virus 1
Human viral diseases
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Retrovirus
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
Title Genetic Association of the Antiviral Restriction Factor TRIM5α with Human Immunodeficiency Virus Type 1 Infection
URI http://jvi.asm.org/content/80/5/2463.abstract
https://www.proquest.com/docview/19833855
https://pubmed.ncbi.nlm.nih.gov/PMC1395369
Volume 80
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKEBIviKvogOEH9lSl5ObEeRyl0zoYD6Ob9ha5ia11WpOpbSaNf8Uf4Z1_wzl2roVxe4mqNLYcny8-Fx9_h5A3oUo8XylhccG45SuXWTyV4PM4ERMyFEE601m-n4KDE__wjJ31et9bWUvFejZMvvzyXMn_SBXugVzxlOw_SLbuFG7Ab5AvXEHCcP0rGSNnNBKutua42vPfy7AsxFJT52NpDlMRfF9X1xlMjydHbHc03n3nmECsCeVP8KxInkokldAnMk_ny2I1QFd14MBKYtK2slvsWXi4E6If68jJaIgl7uXlotnufy-vYSgf5xjKQNPTOs5XIsuVqqM954U-fPW5kPBYE5q9kdngtNiMU3idnI9qA6qdjXo0b9im2qs0OsieLjkMOsoszMh7itZde-U2NaBKhLL2MuybVfNn_eDimYfD08mQ20M2xOcsF_Sz3oNqtwBBXy00bJBwDawcr1GYVZLAhh6tsxsvrucxt2MWY_d3yF0XPBjt7U8-1Btc4IX7FZE9vmqZegjje3vL6JDethxK14aqeK0xrVes4MtWpiRLx2fqZvy2TKjpQ_KgxArdM0B-RHoye0zumWqoN0_IsoQzbcGZ5ooCnGkNZ9qCMzVwphrO375ShDLVUKabUKYayhShTB1aQ_kpOdkfT0cHVlkSxEp8n68tFtlC2nbCZKJgWiMRzkKWpELYaSQTO1JeEvJEMBVEWC5TzFKfp7arQi6Un4bCe0a2sjyTzwmFyZWOtKVjKx8V2SyNkDgJVKDyweyXfRJUkxwnJV8-lm25jLXf7PIYBNXIOUZBYVHXoE_suuGVoYz5c5PtSoqxWC3iDoL6ZKcj16bTkGHdKGj9uhJ0DMoBd_xEJvNiFTsR9zzOWJ-EHfnXXSC5fPefbH6uSebBM2ReEG3_bmQvyP3mS39JttbLQr4CG30929Fo_wH2EeiI
linkProvider Flying Publisher
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Genetic+Association+of+the+Antiviral+Restriction+Factor+TRIM5%CE%B1+with+Human+Immunodeficiency+Virus+Type+1+Infection&rft.jtitle=Journal+of+Virology&rft.au=Emily+C.+Speelmon&rft.au=Devon+Livingston-Rosanoff&rft.au=Shuying+Sue+Li&rft.au=Quyen+Vu&rft.date=2006-03-01&rft.pub=American+Society+for+Microbiology&rft.issn=0022-538X&rft.eissn=1098-5514&rft.volume=80&rft.issue=5&rft.spage=2463&rft_id=info:doi/10.1128%2FJVI.80.5.2463-2471.2006&rft_id=info%3Apmid%2F16474153&rft.externalDBID=n%2Fa&rft.externalDocID=jvi_80_5_2463
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-538X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-538X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-538X&client=summon