Distinct Urinary Metabolic Biomarkers of Human Colorectal Cancer

• Published in: Disease markers Vol. 2022; pp. 1 - 18
• Main Authors: Zhu, Chang, Huang, Fengjie, Li, Yang, Zhu, Chaowei, Zhou, Kejun, Xie, Haihui, Xia, Ligang, Xie, Guoxiang
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2022; John Wiley & Sons, Inc
• Subjects: Adenosine monophosphate; Alanine; Amino acids; AMP; Biomarkers; Biomarkers - metabolism; Biomarkers, Tumor; Cancer; Carbohydrate metabolism; Carbohydrates; Chenodeoxycholic acid; Chromatography; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - metabolism; Diagnosis; Discriminant analysis; Fatty acids; Glycine; Glycolic acid; Glycolysis; Histidine; Humans; Investigations; Lipid metabolism; Lipids; Liquid chromatography; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Medical prognosis; Metabolism; Metabolites; Metabolomics; Metabolomics - methods; Metastasis; p-Hydroxybenzoic acid; Quadrupoles; Scientific imaging; Software; Statistical analysis; Support vector machines; Threonine; Tricarboxylic acid cycle; Urine; Vanillic acid; St Louis Missouri; United States > US; China
• ISSN: 0278-0240; 1875-8630; 1875-8630
• DOI: 10.1155/2022/1758113

Colorectal cancer (CRC) is one of the most commonly diagnosed cancers with high mortality rate due to its poor diagnosis in the early stage. Here, we report a urinary metabolomic study on a cohort of CRC patients (n =67) and healthy controls (n =21) using ultraperformance liquid chromatography tripl...