Searching for viral antibodies and genome in intraocular fluids of patients with Fuchs uveitis and non-infectious uveitis

• Published in: Graefe's archive for clinical and experimental ophthalmology Vol. 251; no. 6; pp. 1607 - 1612
• Main Authors: Cimino, Luca, Aldigeri, Raffaella, Parmeggiani, Maria, Belloni, Lucia, Zotti, Carlo Alberto, Fontana, Luigi, Invernizzi, Alessandro, Salvarani, Carlo, Cappuccini, Luca
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.06.2013; Springer Nature B.V
• Subjects: Adult; Antibodies, Viral - blood; Aqueous Humor - virology; Cytomegalovirus; Cytomegalovirus - genetics; Cytomegalovirus - immunology; Enzyme-Linked Immunosorbent Assay; Eye Infections, Viral - diagnosis; Eye Infections, Viral - virology; Female; Fuchs' Endothelial Dystrophy - diagnosis; Fuchs' Endothelial Dystrophy - virology; Genome, Viral; Herpes simplex virus; Herpesvirus; Herpesvirus 3, Human - genetics; Herpesvirus 3, Human - immunology; Humans; Immunoglobulin G - analysis; Inflammatory Disorders; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Polymerase Chain Reaction; Rubella - diagnosis; Rubella - virology; Rubella virus; Rubella virus - genetics; Rubella virus - immunology; Sensitivity and Specificity; Simplexvirus - genetics; Simplexvirus - immunology; Uveitis, Anterior - diagnosis; Uveitis, Anterior - virology; Varicella-zoster virus; Vitreous Body - virology; Goldmann–Witmer coefficient; Aqueous humor; Fuchs uveitis; Rubella virus; PCR; Intraocular antibody

Background To characterise the polyspecific intraocular antibody synthesis in aqueous humor of patients with Fuchs uveitis and other types of non-infectious uveitis. Methods Aqueous and serum samples collected from 24 patients with Fuchs uveitis, 21 patients with non-infectious uveitis, and 27 healt...