Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1

• Published in: Communications biology Vol. 6; no. 1; pp. 407 - 13
• Main Authors: Sun, Weijia, Li, Yuheng, Li, Jianwei, Tan, Yingjun, Yuan, Xinxin, Meng, Haoye, Ye, Jianting, Zhong, Guohui, Jin, XiaoYan, Liu, Zizhong, Du, Ruikai, Xing, Wenjuan, Zhao, Dingsheng, Song, Jinping, Li, Youyou, Pan, Junjie, Zhao, Yunzhang, Li, Qi, Wang, Aiyuan, Ling, Shukuan, Dai, Rongji, Li, Yingxian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.04.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/95; 38; 38/1; 631/337; 631/80; Aerospace medicine; Biology; Biomedical and Life Sciences; Bone loss; Bone remodeling; Bone turnover; Calcium (intracellular); Calcium signalling; Homeostasis; Intracellular signalling; Laboratories; Life Sciences; Mechanical loading; Mechanical properties; Mechanical stimuli; Molecular modelling; Osteoclasts; Proteins; Shear stress; Unloading

Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical stimulation-induced changes in osteoclast fun...