Nanoparticles for modulating tumor microenvironment to improve drug delivery and tumor therapy

• Published in: Pharmacological research Vol. 126; pp. 97 - 108
• Main Authors: Yang, Shu, Gao, Huile
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2017
• Subjects: Animals; Carcinogenesis - drug effects; Drug delivery; Drug Delivery Systems - methods; Fibroblasts - drug effects; Humans; Hypoxia; Macrophages - drug effects; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Neoplasms - drug therapy; Tumor associated fibroblasts; Tumor microenvironment; Tumor Microenvironment - drug effects; Tumor-associated macrophages; Nanoparticles; Hypoxia; Drug delivery; Tumor microenvironment; Tumor associated fibroblasts; Tumor-associated macrophages

Tumor microenvironment (TME) plays a critical role in tumorigenesis, tumor invasion and metastasis. TME is composed of stroma, endothelial cells, pericytes, fibroblasts, smooth muscle cells, and immune cells, which is characterized by hypoxia, acidosis, and high interstitial fluid pressure. Due to t...