Neurohistochemical biomarkers of the marine neurotoxicant, domoic acid

• Published in: Neurotoxicology and teratology Vol. 27; no. 5; pp. 745 - 752
• Main Authors: Scallet, Andrew C., Schmued, Larry C., Johannessen, Jan N.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2005
• Subjects: Algal blooms; Animals; Argyrophilia; Blood-Brain Barrier; c-Fos; c-Jun; Cetacea; Coloring Agents; Decapoda; Dentate Gyrus - pathology; Excitotoxins; Fluoresceins; Fluorescent Dyes; Fluoro-Jade; Genes, Immediate-Early; GFAP; Glial Fibrillary Acidic Protein - metabolism; Heat-Shock Proteins - metabolism; Hippocampus; HSP-72; Immunohistochemistry; Kainic Acid - analogs & derivatives; Kainic Acid - isolation & purification; Kainic Acid - toxicity; Limbic system; Male; Myelin; Myelin Sheath - metabolism; Nerve Degeneration - chemically induced; Nerve Degeneration - pathology; Nervous System Diseases - chemically induced; Nervous System Diseases - pathology; Neurons - drug effects; Neurons - metabolism; Neurotoxins - toxicity; Organic Chemicals; Phosphates; Rat IgG; Rats; Rats, Sprague-Dawley; Sardinops; Shellfish toxins; Silver Staining; Shellfish toxins; Myelin; c-Fos; Argyrophilia; Limbic system; GFAP; Blood–brain barrier; HSP-72; c-Jun; Algal blooms; Fluoro-Jade; Excitotoxins; Rat IgG; Hippocampus

Domoic acid and its potent excitotoxic analogues glutamic acid and kainic acid, are synthesized by marine algae such as seaweed and phytoplankton. During an algal bloom, domoic acid may enter the food web through its consumption by a variety of marine organisms held in high regard as seafoods by bot...