Progesterone (P4) ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD) - Xie, Bin; Chen, Qiong; Dai, Ziyu; Jiang, Chen; Chen, Xi (Molecular medicine (Cambridge, Mass.), 2024)
Keywords: Airway epithelium; Animals; Apoptosis - drug effects; Cell growth; Cell Line; Cell Proliferation - drug effects; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease (COPD); Cigarette Smoking - adverse effects; Cigarettes; Disease Models, Animal; Humans; Hydrogen Peroxide - metabolism; Laboratory animals; Lungs; Male; Membrane Potential, Mitochondrial - drug effects; Mice; Mice, Inbred C57BL; Mitochondria - drug effects; Mitochondria - metabolism; Mitochondrial DNA; Mitochondrial dysfunction; Oxidative injury; Oxidative stress; Oxidative Stress - drug effects; Pathogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism; Phosphorylation; Progesterone (P4); Progesterone - pharmacology; Proteins; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Pulmonary Disease, Chronic Obstructive - drug therapy; Pulmonary Disease, Chronic Obstructive - etiology; Pulmonary Disease, Chronic Obstructive - metabolism; Reactive Oxygen Species - metabolism; Signal transduction; Signal Transduction - drug effects; Sirtuin 1 - metabolism; Smoke - adverse effects; Smooth muscle; United States--US; China; Shanghai China; Chronic obstructive pulmonary disease (COPD); Mitochondrial dysfunction; Airway epithelium; Progesterone (P4); Oxidative injury