HECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction

• Published in: Cell death & disease Vol. 15; no. 1; p. 86
• Main Authors: Cheng, Zhuo, Huang, Maobo, Li, Wei, Hou, Lei, Jin, Li, Fan, Qijin, Zhang, Linqiang, Li, Chengbin, Zeng, Li, Yang, Chuanyu, Liang, Bin, Li, Fubing, Chen, Ceshi
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 24.01.2024; Nature Publishing Group UK; Nature Publishing Group
• Subjects: Adenosine triphosphate; Arthritis; Arthritis, Gouty; Bacterial infections; Cancer; Crystals; Cytokines; Hospitals; Humans; Infections; Infectious diseases; Inflammasomes; Inflammation; Inflammatory diseases; Interleukin-1beta; Kinases; Life sciences; NIMA-Related Kinases - genetics; NLR Family, Pyrin Domain-Containing 3 Protein - genetics; Oligomerization; Proteins; Therapeutic targets; Ubiquitin-protein ligase; Uric acid

The NLRP3 inflammasome plays an important role in protecting the host from infection and aseptic inflammation, and its regulatory mechanism is not completely understood. Dysregulation of NLRP3 can cause diverse inflammatory diseases. HECTD3 is a E3 ubiquitin ligase of the HECT family that has been r...