Advances in Genetic and Molecular Understanding of Alzheimer’s Disease

• Published in: Genes Vol. 12; no. 8; p. 1247
• Main Authors: Ibanez, Laura, Cruchaga, Carlos, Fernández, Maria Victoria
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.08.2021; MDPI
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - therapy; Alzheimer's disease; Amyloid; Amyloid beta-Peptides - metabolism; Animal cognition; Biomarkers; Biomarkers - metabolism; brain; Brain research; Clinical trials; Dementia; Drug development; elderly; genetics; Humans; Hyperactivity; Hypotheses; Immunosuppressive agents; Kinases; medicine; Metabolism; Mutation; Neurodegenerative diseases; Pathology; Proteins; Review; Tau protein; therapeutics; therapeutics; Alzheimer disease; amyloid β; neuroinflammation; OMICS; biomarkers; tau; TREM2; APOE

Alzheimer’s disease (AD) has become a common disease of the elderly for which no cure currently exists. After over 30 years of intensive research, we have gained extensive knowledge of the genetic and molecular factors involved and their interplay in disease. These findings suggest that different su...