Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms?

• Published in: Oxidative medicine and cellular longevity Vol. 2021; no. 1; p. 8869849
• Main Authors: Piccarducci, Rebecca, Daniele, Simona, Polini, Beatrice, Carpi, Sara, Chico, Lucia, Fusi, Jonathan, Baldacci, Filippo, Siciliano, Gabriele, Bonuccelli, Ubaldo, Nieri, Paola, Martini, Claudia, Franzoni, Ferdinando
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc
• Subjects: Adult; Amyloid beta-Peptides - metabolism; Antioxidants - metabolism; Apolipoproteins; Apolipoproteins E - genetics; Biomarkers - blood; Epigenesis, Genetic; Epigenetics; Exercise; Female; Humans; Leukocytes, Mononuclear - cytology; Leukocytes, Mononuclear - metabolism; Lipids; Male; MicroRNAs - blood; Oxidative Stress; Polymorphism, Genetic; Proteasome Endopeptidase Complex - physiology; Recovery of Function
• ISSN: 1942-0900; 1942-0994; 1942-0994
• DOI: 10.1155/2021/8869849

Alzheimer’s disease (AD) is characterized by proteasome activity impairment, oxidative stress, and epigenetic changes, resulting in β-amyloid (Aβ) production/degradation imbalance. Apolipoprotein E (ApoE) is implicated in Aβ clearance, and particularly, the ApoE ε4 isoform predisposes to AD developm...