Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species

• Published in: The Journal of immunology (1950) Vol. 200; no. 2; pp. 623 - 631
• Main Authors: Kajiwara, Chiaki, Kusaka, Yu, Kimura, Soichiro, Yamaguchi, Tetsuo, Nanjo, Yuta, Ishii, Yoshikazu, Udono, Heiichiro, Standiford, Theodore J, Tateda, Kazuhiro
• Format: Journal Article
• Language: English
• Published: United States American Association of Immunologists 15.01.2018
• Subjects: AMP; AMP-activated protein kinase; AMP-Activated Protein Kinases - metabolism; Animals; Antidiabetics; Bactericidal activity; Bone marrow; Cancer; Cytokines - blood; Cytokines - metabolism; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Disease Models, Animal; Female; Gene Expression Profiling; Glutathione; Immune clearance; Kinases; Legionella; Legionella pneumophila - drug effects; Legionella pneumophila - immunology; Legionnaires' Disease - genetics; Legionnaires' Disease - immunology; Legionnaires' Disease - metabolism; Legionnaires' Disease - microbiology; Macrophages; Macrophages - immunology; Macrophages - metabolism; Macrophages - microbiology; Metformin; Metformin - pharmacology; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; NAD(P)H oxidase; Phosphorylation; Pneumonia; Protective Agents - pharmacology; Reactive oxygen species; Reactive Oxygen Species - metabolism

In Legionella pneumophila infection, macrophages play a critical role in the host defense response. Metformin, an oral drug for type 2 diabetes, is attracting attention as a new supportive therapy against a variety of diseases, such as cancer and infectious diseases. The novel mechanisms for metform...