Metformin Mediates Protection against Legionella Pneumonia through Activation of AMPK and Mitochondrial Reactive Oxygen Species - Kajiwara, Chiaki; Kusaka, Yu; Kimura, Soichiro; Yamaguchi, Tetsuo; Nanjo, Yuta; Ishii, Yoshikazu; Udono, Heiichiro; Standiford, Theodore J; Tateda, Kazuhiro (The Journal of immunology (1950), 2018)
Keywords: AMP; AMP-activated protein kinase; AMP-Activated Protein Kinases - metabolism; Animals; Antidiabetics; Bactericidal activity; Bone marrow; Cancer; Cytokines - blood; Cytokines - metabolism; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Disease Models, Animal; Female; Gene Expression Profiling; Glutathione; Immune clearance; Kinases; Legionella; Legionella pneumophila - drug effects; Legionella pneumophila - immunology; Legionnaires' Disease - genetics; Legionnaires' Disease - immunology; Legionnaires' Disease - metabolism; Legionnaires' Disease - microbiology; Macrophages; Macrophages - immunology; Macrophages - metabolism; Macrophages - microbiology; Metformin; Metformin - pharmacology; Mice; Mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; NAD(P)H oxidase; Phosphorylation; Pneumonia; Protective Agents - pharmacology; Reactive oxygen species; Reactive Oxygen Species - metabolism