High intake of dietary advanced glycation end-products is associated with increased arterial stiffness and inflammation in subjects with type 2 diabetes

• Published in: Nutrition, metabolism, and cardiovascular diseases Vol. 27; no. 11; pp. 978 - 984
• Main Authors: Di Pino, A., Currenti, W., Urbano, F., Scicali, R., Piro, S., Purrello, F., Rabuazzo, A.M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: Adult; advanced glycation end products; Aged; Biomarkers - blood; body mass index; C-Reactive Protein - analysis; Cardiovascular disease; cardiovascular diseases; Carotid Intima-Media Thickness; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - diagnosis; Diabetic Angiopathies - blood; Diabetic Angiopathies - diagnosis; Diabetic Angiopathies - etiology; Diabetic Angiopathies - physiopathology; diet; Diet - adverse effects; Dietary advanced glycation end-products; fat intake; Female; Glycation End Products, Advanced - administration & dosage; Glycation End Products, Advanced - adverse effects; Humans; Inflammation; Inflammation - blood; Inflammation - diagnosis; Inflammation - etiology; Male; metabolism; Middle Aged; noninsulin-dependent diabetes mellitus; nutrition risk assessment; processing technology; Pulse Wave Analysis; Receptor for Advanced Glycation End Products - blood; regression analysis; Risk Assessment; Risk Factors; Soluble receptor for advanced glycation endproducts; systolic blood pressure; Type 2 diabetes; Vascular Stiffness; Type 2 diabetes; Dietary advanced glycation end-products; Cardiovascular disease; Inflammation; Soluble receptor for advanced glycation endproducts

Modern diets are high in advanced glycation end-products (dAGEs), derived from processing methods, exerting a pivotal role in promoting atherosclerotic risk. In this cross-sectional study we investigate the relationship between dAGE intake, arterial stiffness, inflammatory profile and macronutrient...