Association of HLA Genotype With T-Cell Activation in Human Immunodeficiency Virus (HIV) and HIV/Hepatitis C Virus–Coinfected Women

• Published in: The Journal of infectious diseases Vol. 221; no. 7; pp. 1156 - 1166
• Main Authors: Kovacs, Andrea A Z, Kono, Naoko, Wang, Chia-Hao, Wang, Daidong, Frederick, Toni, Operskalski, Eva, Tien, Phyllis C, French, Audrey L, Minkoff, Howard, Kassaye, Seble, T. Golub, Elizabeth, Aouizerat, Bradley E, Kuniholm, Mark H, Millstein, Joshua
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 16.03.2020
• Subjects: Adolescent; Adult; Aged; Alleles; Antiretroviral drugs; Antiretroviral Therapy, Highly Active; CD38 antigen; CD4 antigen; CD8 antigen; Cell activation; Cohort Studies; Coinfection - complications; Coinfection - epidemiology; Coinfection - genetics; Coinfection - immunology; DQA1 protein; Drb1 protein; Female; Genotype; Genotypes; Hepatitis; Hepatitis C; Hepatitis C - complications; Hepatitis C - epidemiology; Hepatitis C - genetics; Hepatitis C - immunology; Highly active antiretroviral therapy; Histocompatibility antigen HLA; HIV; HIV Infections - complications; HIV Infections - epidemiology; HIV Infections - genetics; HIV Infections - immunology; HLA Antigens - genetics; Human immunodeficiency virus; Humans; Lymphocyte Activation - genetics; Lymphocytes; Lymphocytes T; Major and Brief Reports; Middle Aged; Pathogenesis; Regression analysis; Womens health; Young Adult; HCV; HIV; HLA; immune activation; T-cell activation

Abstract Background Global immune activation and HLA alleles are each associated with the pathogenesis of human immunodeficiency virus (HIV) and hepatitis C virus . Methods We evaluated the relationship between 44 HLA class I and 28 class II alleles and percentages of activated CD8 (CD8+CD38+DR+) an...