Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification - Guilinger, John P; Thompson, David B; Liu, David R (Nature biotechnology, 2014)
Keywords: 631/1647/1511; Agriculture; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bioinformatics; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR-Associated Protein 9; CRISPR-Cas Systems; Deoxyribonucleases, Type II Site-Specific - chemistry; Deoxyribonucleases, Type II Site-Specific - genetics; Deoxyribonucleic acid; DNA; Endonucleases - chemistry; Endonucleases - genetics; Gene Editing - methods; Genetic engineering; Genome, Human; Genomics; Humans; Life Sciences; Protein Multimerization; Recombinant Fusion Proteins - chemistry; Recombinant Fusion Proteins - genetics; RNA - genetics