MiR‐205 promotes endothelial progenitor cell angiogenesis and deep vein thrombosis recanalization and resolution by targeting PTEN to regulate Akt/autophagy pathway and MMP2 expression

• Published in: Journal of cellular and molecular medicine Vol. 23; no. 12; pp. 8493 - 8504
• Main Authors: Sun, Li‐Li, Xiao, Lun, Du, Xiao‐Long, Hong, Lei, Li, Cheng‐Long, Jiao, Jian, Li, Wen‐Dong, Li, Xiao‐Qiang
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.12.2019; John Wiley and Sons Inc
• Subjects: Actin; AKT protein; Angiogenesis; Animals; Apoptosis; Apoptosis - genetics; Autophagy; Autophagy - genetics; Blood clots; Cancer therapies; Cell adhesion & migration; Cell growth; Cell Movement - genetics; Cells, Cultured; Cholecystokinin; deep vein thrombosis; endothelial progenitor cell; Endothelial Progenitor Cells - metabolism; Filaments; Flow cytometry; Gelatinase A; Gene amplification; Gene Expression Regulation; Gene regulation; Homing behavior; Humans; Immunofluorescence; Male; Matrix Metalloproteinase 2 - genetics; Matrix Metalloproteinase 2 - metabolism; Mice, Nude; microRNA; MicroRNAs; MicroRNAs - genetics; migration; miRNA; Neovascularization, Physiologic - genetics; Original; Ovarian cancer; Phagocytosis; Progenitor cells; Protein expression; Proteins; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; PTEN protein; Signal Transduction - genetics; Stem cells; Studies; Thrombolysis; Thrombosis; Transcription; Vascular diseases; Veins & arteries; Venous Thrombosis - genetics; Venous Thrombosis - metabolism; Wound healing; migration; endothelial progenitor cell; microRNA; deep vein thrombosis; angiogenesis

MicroRNAs (MiRNAs, MiRs) represent a class of conserved small non‐coding RNAs that affect post‐transcriptional gene regulation and play a vital role in angiogenesis, proliferation, apoptosis, migration and invasion. They are essential for a wide range of physiological and pathological processes, esp...