Impaired erythropoietin synthesis in chronic kidney disease is caused by alterations in extracellular matrix composition

• Published in: Journal of cellular and molecular medicine Vol. 22; no. 1; pp. 302 - 314
• Main Authors: Olmos, Gemma, Muñoz‐Félix, José M., Mora, Inés, Müller, Anton Gerhard, Ruiz‐Torres, Maria Piedad, López‐Novoa, José M., Rodríguez‐Puyol, Diego
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.01.2018; John Wiley and Sons Inc
• Subjects: Accumulation; anaemia; Anemia; Animals; Basic Helix-Loop-Helix Transcription Factors - metabolism; Cell Line; chronic kidney disease; Collagen; Collagen (type I); Collagen (type IV); Collagen Type I - pharmacology; Down-Regulation - drug effects; Erythropoietin; Erythropoietin - biosynthesis; Erythropoietin - genetics; Erythropoietin - metabolism; Extracellular matrix; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibrosis; Focal adhesion kinase; Focal Adhesion Protein-Tyrosine Kinases - metabolism; Gene expression; Humans; hypoxia‐inducible factor; Inactivation; Inhibition; Kidney - pathology; Kidney diseases; Kidneys; Mice; Mice, Inbred C57BL; Original; Phosphorylation; Proteasome Endopeptidase Complex - metabolism; Proteasome Inhibitors - pharmacology; Proteasomes; Proteins; Proteolysis - drug effects; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - pathology; RNA, Messenger - genetics; RNA, Messenger - metabolism; Ureteral Obstruction - pathology; United Kingdom > UK; United States > US; Spain; chronic kidney disease; fibrosis; hypoxia-inducible factor; anaemia; erythropoietin

Renal fibrosis and anaemia are two of the most relevant events in chronic kidney disease. Fibrosis is characterized by the accumulation of extracellular matrix proteins in the glomeruli and tubular interstitium. Anaemia is the consequence of a decrease in erythropoietin production in fibrotic kidney...