Microglia maintain the normal structure and function of the hippocampal astrocyte network

• Published in: Glia Vol. 70; no. 7; pp. 1359 - 1379
• Main Authors: Du, Yixing, Brennan, Faith H., Popovich, Phillip G., Zhou, Min
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.07.2022; Wiley Subscription Services, Inc
• Subjects: Animals; Astrocytes; Astrocytes - metabolism; Connexin 30 - metabolism; Coupling; Depletion; Hippocampus; Hippocampus - metabolism; Lipopolysaccharides; Long-term potentiation; Long-Term Potentiation - physiology; Mice; Microglia; Microglia - metabolism; Neural networks; Neuronal Plasticity - physiology; Priming; Structure-function relationships; Synaptic plasticity; Synaptic transmission; Synaptic Transmission - physiology; synaptic transmission; astrocytes; synaptic plasticity; hippocampus; microglia

Microglial control of activity‐dependent plasticity and synaptic remodeling in neuronal networks has been the subject of intense research in the past several years. Although microglia–neuron interactions have been extensively studied, less is known about how microglia influence astrocyte‐dependent c...