The Psymberin Story-Biological Properties and Approaches towards Total and Analogue Syntheses

• Published in: Angewandte Chemie International Edition Vol. 52; no. 42; pp. 10960 - 10985
• Main Authors: Bielitza, Max, Pietruszka, Jörg
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 11.10.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Animals; anticancer agent; Biological Products - chemistry; Biological properties; biosynthesis; Coumarins - chemical synthesis; Coumarins - chemistry; Humans; Marine Biology; Molecular Structure; natural products; Structure-Activity Relationship; structure-activity relationships; total synthesis; natural products; total synthesis; structure-activity relationships; anticancer agent; biosynthesis

Psymberin is a marine natural product which has attracted a great deal of interest since its isolation: While the highly cytotoxic compound was detected early on as an ingredient in a marine sponge, it took over a decade and 600 additional samples for the structure to eventually be assigned. In the...