Novel factors potentially initiating acute antibody‐mediated rejection in pig kidney xenografts despite an efficient immunosuppressive regimen

• Published in: Xenotransplantation Vol. 31; no. 2; pp. e12859 - n/a
• Main Authors: Kinoshita, Kohei, Maenaka, Akihiro, Rosales, Ivy A., Karadagi, Ahmad, Tomosugi, Toshihide, Ayares, David, Lederman, Seth, Colvin, Robert B., Kawai, Tatsuo, Pierson, Richard N., Kobayashi, Takaaki, Cooper, David K. C.
• Format: Journal Article
• Language: English
• Published: Denmark Wiley 01.03.2024; Wiley Subscription Services, Inc
• Subjects: ABO system; Animals; antibody‐mediated; baboon; CD40L protein; Female; Graft rejection; Graft Rejection - immunology; Heterografts - immunology; Immune response; Immunosuppression Therapy - methods; Immunosuppressive Agents; kidney; Kidney transplantation; Kidney Transplantation - adverse effects; Kidney Transplantation - methods; Male; Membranous nephropathy; Monoclonal antibodies; Nephropathy; Papio; pig; Proteinuria; Pyelonephritis; rejection; Swine; Transplantation, Heterologous - adverse effects; Transplantation, Heterologous - methods; Xenografts; xenotransplantation; kidney; xenotransplantation; antibody‐mediated; baboon; rejection; pig

Antibody‐mediated rejection (AMR) is a common cause of graft failure after pig‐to‐nonhuman primate organ transplantation, even when the graft is from a pig with multiple genetic modifications. The specific factors that initiate AMR are often uncertain. We report two cases of pig kidney transplantati...