Muscarinic receptor hyperpolarizes cochlear hair cells of chick by activating Ca(2+)-activated K+ channels

• Published in: The Journal of physiology Vol. 442; no. 1; pp. 669 - 690
• Main Authors: Shigemoto, T, Ohmori, H
• Format: Journal Article
• Language: English
• Published: England The Physiological Society 01.10.1991
• Subjects: Acetylcholine - pharmacology; Animals; Atropine - pharmacology; Calcium - metabolism; Chickens; Dose-Response Relationship, Drug; Hair Cells, Auditory - physiology; Membrane Potentials - physiology; Potassium - metabolism; Potassium Channels - physiology; Quinine - pharmacology; Receptors, Muscarinic - physiology

1. Electrical responses to extracellularly applied acetylcholine (ACh) and to intracellularly introduced substances were studied in isolated short and tall hair cells from the chick cochlear organ by a whole-cell voltage clamp technique using a patch electrode. These cells were isolated without usin...