Serum Circ‐FAF1/Circ‐ELP3: A novel potential biomarker for breast cancer diagnosis

Background Recently, measurement of serum circular RNAs (circRNAs) as a non‐invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ‐ELP3 and Circ‐FAF1, separately and simultaneously, for diagnosis of patients with breast ca...

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Published inJournal of clinical laboratory analysis Vol. 35; no. 11; pp. e24008 - n/a
Main Authors Omid‐Shafaat, Ramtin, Moayeri, Hassan, Rahimi, Karim, Menbari, Mohammad‐Nazir, Vahabzadeh, Zakaria, Hakhamaneshi, Mohammad‐Saied, Nouri, Bijan, Ghaderi, Bayazid, Abdi, Mohammad
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.11.2021
John Wiley and Sons Inc
Subjects
Adult
Antigens
Biomarkers
Biomarkers, Tumor - blood
Breast cancer
Breast carcinoma
Breast Neoplasms - blood
Breast Neoplasms - diagnosis
Breast Neoplasms - epidemiology
cancer biomarker
Chemotherapy
Circ‐ELP3
Circ‐FAF1
Diagnosis
diagnostic efficiency
Epidermal growth factor
Estrogens
Female
Gene expression
Humans
Laboratories
Mammography
Medical diagnosis
Medical screening
Metastasis
Middle Aged
RNA polymerase
RNA, Circular - blood
ROC Curve
Tumor markers
Tumors
United States > US
Circ-FAF1
breast cancer
diagnostic efficiency
cancer biomarker
Circ-ELP3
Online AccessGet full text

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Abstract Background Recently, measurement of serum circular RNAs (circRNAs) as a non‐invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ‐ELP3 and Circ‐FAF1, separately and simultaneously, for diagnosis of patients with breast cancer. Methods Seventy‐eight female patients diagnosed as primary breast cancer participated in this study. We measured the level of circRNAs in serum specimens of the studied subjects. A receiver operating characteristic (ROC) curve was plotted and the diagnostic efficiency for both circRNAs was determined. Results Compared to non‐cancerous controls, Circ‐ELP3 was upregulated in breast cancer patients (p‐value = 0.004). On the other hand, serum Circ‐FAF1 was seen to be decreased in breast cancer patients than controls (p‐value = 0.001). According to ROC curve results, the area under the curve (AUC) for Circ‐ELP3 and Circ‐FAF1 was 0.733 and 0.787, respectively. Furthermore, the calculated sensitivity and specificity for Circ‐ELP3 and Circ‐FAF1 were 65, 64% and 77, 74%, respectively. Merging both circRNAs increased the diagnostic efficiency, with a better AUC, sensitivity and specificity values of 0.891, 96 and 62%, respectively. Conclusion Briefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ‐ELP3 and Circ‐FAF1 as a non‐invasive marker, in detection of breast carcinomas. Circ‐ELP3 is overexpressed in breast cancer serum specimens. Circ‐FAF1 is decreased in serum sample of patients with breast cancer. Diagnostic efficiency of serum Circ‐FAF1 is higher than Circ‐ELP3 and both of them have the appropriate diagnostic value for breast cancer detection. Combined measurement of Circ‐ELP3 and Circ‐FAF1 has a high diagnostic value and may be considered a diagnostic biomarker for breast cancer detection.
AbstractList Circ‐ELP3 is overexpressed in breast cancer serum specimens. Circ‐FAF1 is decreased in serum sample of patients with breast cancer. Diagnostic efficiency of serum Circ‐FAF1 is higher than Circ‐ELP3 and both of them have the appropriate diagnostic value for breast cancer detection. Combined measurement of Circ‐ELP3 and Circ‐FAF1 has a high diagnostic value and may be considered a diagnostic biomarker for breast cancer detection.
Background Recently, measurement of serum circular RNAs (circRNAs) as a non‐invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ‐ELP3 and Circ‐FAF1, separately and simultaneously, for diagnosis of patients with breast cancer. Methods Seventy‐eight female patients diagnosed as primary breast cancer participated in this study. We measured the level of circRNAs in serum specimens of the studied subjects. A receiver operating characteristic (ROC) curve was plotted and the diagnostic efficiency for both circRNAs was determined. Results Compared to non‐cancerous controls, Circ‐ELP3 was upregulated in breast cancer patients (p‐value = 0.004). On the other hand, serum Circ‐FAF1 was seen to be decreased in breast cancer patients than controls (p‐value = 0.001). According to ROC curve results, the area under the curve (AUC) for Circ‐ELP3 and Circ‐FAF1 was 0.733 and 0.787, respectively. Furthermore, the calculated sensitivity and specificity for Circ‐ELP3 and Circ‐FAF1 were 65, 64% and 77, 74%, respectively. Merging both circRNAs increased the diagnostic efficiency, with a better AUC, sensitivity and specificity values of 0.891, 96 and 62%, respectively. Conclusion Briefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ‐ELP3 and Circ‐FAF1 as a non‐invasive marker, in detection of breast carcinomas. Circ‐ELP3 is overexpressed in breast cancer serum specimens. Circ‐FAF1 is decreased in serum sample of patients with breast cancer. Diagnostic efficiency of serum Circ‐FAF1 is higher than Circ‐ELP3 and both of them have the appropriate diagnostic value for breast cancer detection. Combined measurement of Circ‐ELP3 and Circ‐FAF1 has a high diagnostic value and may be considered a diagnostic biomarker for breast cancer detection.
Recently, measurement of serum circular RNAs (circRNAs) as a non-invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ-ELP3 and Circ-FAF1, separately and simultaneously, for diagnosis of patients with breast cancer.BACKGROUNDRecently, measurement of serum circular RNAs (circRNAs) as a non-invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ-ELP3 and Circ-FAF1, separately and simultaneously, for diagnosis of patients with breast cancer.Seventy-eight female patients diagnosed as primary breast cancer participated in this study. We measured the level of circRNAs in serum specimens of the studied subjects. A receiver operating characteristic (ROC) curve was plotted and the diagnostic efficiency for both circRNAs was determined.METHODSSeventy-eight female patients diagnosed as primary breast cancer participated in this study. We measured the level of circRNAs in serum specimens of the studied subjects. A receiver operating characteristic (ROC) curve was plotted and the diagnostic efficiency for both circRNAs was determined.Compared to non-cancerous controls, Circ-ELP3 was upregulated in breast cancer patients (p-value = 0.004). On the other hand, serum Circ-FAF1 was seen to be decreased in breast cancer patients than controls (p-value = 0.001). According to ROC curve results, the area under the curve (AUC) for Circ-ELP3 and Circ-FAF1 was 0.733 and 0.787, respectively. Furthermore, the calculated sensitivity and specificity for Circ-ELP3 and Circ-FAF1 were 65, 64% and 77, 74%, respectively. Merging both circRNAs increased the diagnostic efficiency, with a better AUC, sensitivity and specificity values of 0.891, 96 and 62%, respectively.RESULTSCompared to non-cancerous controls, Circ-ELP3 was upregulated in breast cancer patients (p-value = 0.004). On the other hand, serum Circ-FAF1 was seen to be decreased in breast cancer patients than controls (p-value = 0.001). According to ROC curve results, the area under the curve (AUC) for Circ-ELP3 and Circ-FAF1 was 0.733 and 0.787, respectively. Furthermore, the calculated sensitivity and specificity for Circ-ELP3 and Circ-FAF1 were 65, 64% and 77, 74%, respectively. Merging both circRNAs increased the diagnostic efficiency, with a better AUC, sensitivity and specificity values of 0.891, 96 and 62%, respectively.Briefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ-ELP3 and Circ-FAF1 as a non-invasive marker, in detection of breast carcinomas.CONCLUSIONBriefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ-ELP3 and Circ-FAF1 as a non-invasive marker, in detection of breast carcinomas.
BackgroundRecently, measurement of serum circular RNAs (circRNAs) as a non‐invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ‐ELP3 and Circ‐FAF1, separately and simultaneously, for diagnosis of patients with breast cancer.MethodsSeventy‐eight female patients diagnosed as primary breast cancer participated in this study. We measured the level of circRNAs in serum specimens of the studied subjects. A receiver operating characteristic (ROC) curve was plotted and the diagnostic efficiency for both circRNAs was determined.ResultsCompared to non‐cancerous controls, Circ‐ELP3 was upregulated in breast cancer patients (p‐value = 0.004). On the other hand, serum Circ‐FAF1 was seen to be decreased in breast cancer patients than controls (p‐value = 0.001). According to ROC curve results, the area under the curve (AUC) for Circ‐ELP3 and Circ‐FAF1 was 0.733 and 0.787, respectively. Furthermore, the calculated sensitivity and specificity for Circ‐ELP3 and Circ‐FAF1 were 65, 64% and 77, 74%, respectively. Merging both circRNAs increased the diagnostic efficiency, with a better AUC, sensitivity and specificity values of 0.891, 96 and 62%, respectively.ConclusionBriefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ‐ELP3 and Circ‐FAF1 as a non‐invasive marker, in detection of breast carcinomas.
Recently, measurement of serum circular RNAs (circRNAs) as a non-invasive tumor marker has been considered more. We designed the present study to investigate the diagnostic efficiency of serum Circ-ELP3 and Circ-FAF1, separately and simultaneously, for diagnosis of patients with breast cancer. Seventy-eight female patients diagnosed as primary breast cancer participated in this study. We measured the level of circRNAs in serum specimens of the studied subjects. A receiver operating characteristic (ROC) curve was plotted and the diagnostic efficiency for both circRNAs was determined. Compared to non-cancerous controls, Circ-ELP3 was upregulated in breast cancer patients (p-value = 0.004). On the other hand, serum Circ-FAF1 was seen to be decreased in breast cancer patients than controls (p-value = 0.001). According to ROC curve results, the area under the curve (AUC) for Circ-ELP3 and Circ-FAF1 was 0.733 and 0.787, respectively. Furthermore, the calculated sensitivity and specificity for Circ-ELP3 and Circ-FAF1 were 65, 64% and 77, 74%, respectively. Merging both circRNAs increased the diagnostic efficiency, with a better AUC, sensitivity and specificity values of 0.891, 96 and 62%, respectively. Briefly, our results revealed the high diagnostic value for combined circRNAs panel, including Circ-ELP3 and Circ-FAF1 as a non-invasive marker, in detection of breast carcinomas.
Author Omid‐Shafaat, Ramtin
Vahabzadeh, Zakaria
Abdi, Mohammad
Nouri, Bijan
Menbari, Mohammad‐Nazir
Moayeri, Hassan
Rahimi, Karim
Hakhamaneshi, Mohammad‐Saied
Ghaderi, Bayazid
AuthorAffiliation 1 Student Research Committee Kurdistan University of Medical Sciences Sanandaj Iran
6 Department of Clinical Biochemistry Faculty of Medicine Kurdistan University of Medical Sciences Sanandaj Iran
2 Department of Surgery Faculty of Medicine Kurdistan University of Medical Sciences Sanandaj Iran
8 Cancer and Immunology Research Center Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj Iran
7 Department of Epidemiology and Biostatistics Faculty of Medicine Kurdistan University of Medical Sciences Sanandaj Iran
3 Department of Molecular Biology and Genetics Gene Expression and Gene Medicine Aarhus University Aarhus Denmark
4 Interdisciplinary Nanoscience Center Aarhus University Aarhus Denmark
5 Cellular and Molecular Research Center Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj Iran
AuthorAffiliation_xml – name: 3 Department of Molecular Biology and Genetics Gene Expression and Gene Medicine Aarhus University Aarhus Denmark
– name: 6 Department of Clinical Biochemistry Faculty of Medicine Kurdistan University of Medical Sciences Sanandaj Iran
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– name: 4 Interdisciplinary Nanoscience Center Aarhus University Aarhus Denmark
– name: 8 Cancer and Immunology Research Center Research Institute for Health Development Kurdistan University of Medical Sciences Sanandaj Iran
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– name: 7 Department of Epidemiology and Biostatistics Faculty of Medicine Kurdistan University of Medical Sciences Sanandaj Iran
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34545638$$D View this record in MEDLINE/PubMed
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2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
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Issue 11
Keywords Circ-FAF1
breast cancer
diagnostic efficiency
cancer biomarker
Circ-ELP3
Language English
License Attribution
2021 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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Notes Funding information
This work was supported by a research grant from Kurdistan University of Medical Sciences (Grant/Award Numbers: ‘IR.MUK.REC.1398.170’)
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Snippet Background Recently, measurement of serum circular RNAs (circRNAs) as a non‐invasive tumor marker has been considered more. We designed the present study to...
Recently, measurement of serum circular RNAs (circRNAs) as a non-invasive tumor marker has been considered more. We designed the present study to investigate...
BackgroundRecently, measurement of serum circular RNAs (circRNAs) as a non‐invasive tumor marker has been considered more. We designed the present study to...
Circ‐ELP3 is overexpressed in breast cancer serum specimens. Circ‐FAF1 is decreased in serum sample of patients with breast cancer. Diagnostic efficiency of...
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StartPage e24008
SubjectTerms Adult
Antigens
Biomarkers
Biomarkers, Tumor - blood
Breast cancer
Breast carcinoma
Breast Neoplasms - blood
Breast Neoplasms - diagnosis
Breast Neoplasms - epidemiology
cancer biomarker
Chemotherapy
Circ‐ELP3
Circ‐FAF1
Diagnosis
diagnostic efficiency
Epidermal growth factor
Estrogens
Female
Gene expression
Humans
Laboratories
Mammography
Medical diagnosis
Medical screening
Metastasis
Middle Aged
RNA polymerase
RNA, Circular - blood
ROC Curve
Tumor markers
Tumors
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Title Serum Circ‐FAF1/Circ‐ELP3: A novel potential biomarker for breast cancer diagnosis
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