Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

• Published in: Journal of cellular and molecular medicine Vol. 21; no. 4; pp. 648 - 657
• Main Authors: Yu, Haitao, Guo, Pengyi, Xie, Xiaozai, Wang, Yi, Chen, Gang
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2017; John Wiley and Sons Inc
• Subjects: Animals; Apoptosis; Artemisinin; Autophagy; Cell death; Cell proliferation; Cell size; Chemical compounds; erastin; Ferroptosis; Glutathione peroxidase; Hepatocellular carcinoma; Humans; Iron - metabolism; iron‐dependent cell death; Kidney cancer; Lipids; Liver cancer; Metabolic Networks and Pathways; Mevalonic acid; Mitochondria; Models, Biological; Morphology; Necrosis; Neoplasms - pathology; Ovarian cancer; Oxidation; Pancreas; Pancreatic cancer; Pancreatic carcinoma; Peroxide; Renal cell carcinoma; Review; Reviews; Sulfur; Tumors; tumourous diseases; erastin; ferroptosis; tumourous diseases; iron-dependent cell death

Ferroptosis is a newly discovered type of cell death that differs from traditional apoptosis and necrosis and results from iron‐dependent lipid peroxide accumulation. Ferroptotic cell death is characterized by cytological changes, including cell volume shrinkage and increased mitochondrial membrane...