Up‐regulation of LIMK1 expression in prostate cancer is correlated with poor pathological features, lymph node metastases and biochemical recurrence

• Published in: Journal of cellular and molecular medicine Vol. 24; no. 8; pp. 4698 - 4706
• Main Authors: Huang, Jin‐Bei, Wu, Yu‐Peng, Lin, Yun‐Zhi, Cai, Hai, Chen, Shao‐Hao, Sun, Xiong‐Lin, Li, Xiao‐Dong, Wei, Yong, Zheng, Qing‐Shui, Xu, Ning, Xue, Xue‐Yi
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.04.2020; John Wiley and Sons Inc
• Subjects: advanced pathological features; Aged; Androgens; Antigens; biochemical recurrence; Cancer surgery; Cancer therapies; Cell cycle; Disease-Free Survival; Endocrine therapy; Gene Expression Regulation, Neoplastic - genetics; Humans; Hyperplasia; Kaplan-Meier Estimate; LIM domain kinase 1; LIM kinase; Lim Kinases - genetics; lymph node metastasis; Lymph nodes; Lymph Nodes - metabolism; Lymph Nodes - pathology; Lymphatic Metastasis - genetics; Lymphatic Metastasis - pathology; Lymphatic system; Male; Medical prognosis; Medical research; Metastases; Metastasis; Middle Aged; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; Original; Prostate - metabolism; Prostate - pathology; Prostate cancer; Prostatectomy; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Radiation therapy; Regression analysis; Risk factors; Seminal vesicle; Survival Analysis; Tumors; Up-regulation; LIM domain kinase 1; prostate cancer; advanced pathological features; biochemical recurrence; lymph node metastasis

This study aimed to explore the association between LIM domain kinase 1 (LIMK1) expression in prostate cancer (PCa) tissues with advanced pathological features, lymph node metastases and biochemical recurrence. A total of 279 PCa specimens from patients who underwent radical prostatectomy and 50 ben...