MicroRNA‐153‐3p increases autophagy in sevoflurane‐preconditioned mice to protect against ischaemic/reperfusion injury after knee arthroplasty

• Published in: Journal of cellular and molecular medicine Vol. 24; no. 9; pp. 5330 - 5340
• Main Authors: Qiu, Shuang, Liu, Benjuan, Mo, Yanshuai, Wang, Xueqin, Zhong, Lina, Han, Xiao, Mi, Fuli
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2020; John Wiley and Sons Inc
• Subjects: Animal models; Animals; Apoptosis; Arthroplasty (knee); Arthroplasty, Replacement, Knee - adverse effects; Autophagy; Autophagy - drug effects; Autophagy - genetics; Beclin-1 - metabolism; Beclin1; B‐cell lymphoma‐2; Cartilage; Chondrocytes; Chondrocytes - drug effects; Chondrocytes - metabolism; Chondrocytes - pathology; Collagen; Dehydrogenases; Down-Regulation - drug effects; Down-Regulation - genetics; Gene expression; Humans; ischaemic/reperfusion injury; Ischemia; Ischemic Preconditioning; Joint replacement surgery; Joint surgery; Kinases; Laboratory animals; Lymphoma; Male; Mice; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; microRNA‐153‐3p; miRNA; Models, Biological; Original; Polymerase chain reaction; Prostheses; Proto-Oncogene Proteins c-bcl-2 - metabolism; Reperfusion; Reperfusion Injury - drug therapy; Reperfusion Injury - etiology; Reperfusion Injury - genetics; Sevoflurane; Sevoflurane - pharmacology; Sevoflurane - therapeutic use; total knee arthroplasty; Up-Regulation - drug effects; Up-Regulation - genetics; total knee arthroplasty; autophagy; Beclin1; sevoflurane; ischaemic/reperfusion injury; B-cell lymphoma-2; microRNA-153-3p

The use of tourniquet during total knee arthroplasty (TKA) can result in ischaemia/reperfusion injury (IRI). Of interest, microRNAs (miRs) are reported to be involved in various kinds of IRI due to their ability in modulating autophagy. Therefore, the study aimed to investigate the effect of miR‐153...