Integrated Population Pharmacokinetic Analysis of Rivaroxaban Across Multiple Patient Populations

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 7; no. 5; pp. 309 - 320
• Main Authors: Willmann, Stefan, Zhang, Liping, Frede, Matthias, Kubitza, Dagmar, Mueck, Wolfgang, Schmidt, Stephan, Solms, Alexander, Yan, Xiaoyu, Garmann, Dirk
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.05.2018; John Wiley and Sons Inc
• Subjects: Age; Anticoagulants; Clinical trials; Drug dosages; Embolisms; Joint replacement surgery; Patients; Pharmacokinetics; Prevention; R&D; Research & development; Stroke; Studies; United States > US

The population pharmacokinetics (PK) of rivaroxaban have been evaluated in several population‐specific models. We developed an integrated population PK model using pooled data from 4,918 patients in 7 clinical trials across all approved indications. Effects of gender, age, and weight on apparent cle...