Transcriptional instability is not a universal attribute of aging

• Published in: Aging cell Vol. 6; no. 6; pp. 775 - 782
• Main Authors: Warren, Luigi A., Rossi, Derrick J., Schiebinger, Geoffrey R., Weissman, Irving L., Kim, Stuart K., Quake, Stephen R.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2007
• Subjects: aging; Aging - genetics; Animals; Cellular Senescence - genetics; FACS; Flow Cytometry; gene regulation; hematopoiesis; Hematopoietic Stem Cells - metabolism; Mice; Mice, Inbred C57BL; RNA, Messenger - analysis; RNA, Messenger - metabolism; single‐cell analysis; stem cells; Transcription, Genetic

Summary It has been proposed that cumulative somatic mutations contribute to the aging process by disrupting the transcriptional networks that regulate cell structure and function. Experimental support for this model emerged from a recent study of cardiomyocytes that showed a dramatic increase in th...