Single nucleotide polymorphisms located in TNFA, IL1RN, IL6R, and IL6 genes are associated with COVID‐19 risk and severity in an Iranian population

• Published in: Cell biology international Vol. 46; no. 7; pp. 1109 - 1127
• Main Authors: Rokni, Mohsen, Sarhadi, Mohammad, Heidari Nia, Milad , Mohamed Khosroshahi, Leila, Asghari, Somaye, Sargazi, Saman, Mirinejad, Shekoufeh, Saravani, Ramin
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.07.2022; John Wiley and Sons Inc
• Subjects: Alleles; Clinical features; Coronaviruses; COVID-19; Cytokines; Genetic diversity; Immune system; Immunogenetics; Inflammation; Interleukin 1; Interleukin 6; Interleukin 6 receptors; Leukocytes (neutrophilic); Lymphocytes; Pathogenesis; Patients; Polymerase chain reaction; polymorphism; proinflammatory cytokine; Respiratory distress syndrome; SARS‐CoV‐2; Severe acute respiratory syndrome coronavirus 2; Single-nucleotide polymorphism; COVID-19; proinflammatory cytokine; Clinical features; SARS-CoV-2; polymorphism; Pathogenesis
• ISSN: 1065-6995; 1095-8355; 1095-8355
• DOI: 10.1002/cbin.11807

Cytokines play pivotal functions in coronavirus disease 2019 (COVID‐19) pathogenesis. However, little is known about the rationale and importance of genetic variations associated with immune system responses, so‐called “immunogenetic profiling.” We studied whether polymorphisms of IL6, IL6R, TNFA, a...