Population Pharmacokinetics of Apixaban in Subjects With Nonvalvular Atrial Fibrillation

• Published in: CPT: pharmacometrics and systems pharmacology Vol. 7; no. 11; pp. 728 - 738
• Main Authors: Cirincione, Brenda, Kowalski, Kenneth, Nielsen, Jace, Roy, Amit, Thanneer, Neelima, Byon, Wonkyung, Boyd, Rebecca, Wang, Xiaoli, Leil, Tarek, LaCreta, Frank, Ueno, Takayo, Oishi, Masayo, Frost, Charles
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.11.2018; John Wiley and Sons Inc
• Subjects: Age; Anticoagulants; Cardiac arrhythmia; Clinical trials; Embolisms; Employees; Pharmacokinetics; Studies; Thrombosis; Japan

This analysis describes the population pharmacokinetics (PPK) of apixaban in nonvalvular atrial fibrillation (NVAF) subjects, and quantifies the impact of intrinsic and extrinsic factors on exposure. The PPK model was developed using data from phase I–III studies. Apixaban exposure was characterized...