Scandium-Catalyzed Silylation of Aromatic CH Bonds

Regioselective, hydrogen‐acceptor‐free CH bond silylation of anisoles or alkoxy‐substituted benzenes with hydrosilanes was achieved by use of a half‐sandwich scandium catalyst. The reaction proceeds through ortho‐CH activation of an anisole compound by a scandium hydride species followed by the si...

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Published inAngewandte Chemie (International ed.) Vol. 50; no. 45; pp. 10720 - 10723
Main Authors Oyamada, Juzo, Nishiura, Masayoshi, Hou, Zhaomin
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 04.11.2011
WILEY‐VCH Verlag
Subjects
anisoles
CH activation
hydrosilanes
scandium
silylation
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Summary:Regioselective, hydrogen‐acceptor‐free CH bond silylation of anisoles or alkoxy‐substituted benzenes with hydrosilanes was achieved by use of a half‐sandwich scandium catalyst. The reaction proceeds through ortho‐CH activation of an anisole compound by a scandium hydride species followed by the silylation of the resulting scandium 2‐anisyl species with a hydrosilane (see scheme).
Bibliography:This work was partly supported by a Grant-in-Aid for Scientific Research (S) from JSPS (No. 21225004).
JSPS - No. 21225004
ark:/67375/WNG-68DXNHBQ-0
ArticleID:ANIE201105636
istex:0E37F8DB36D2DBEBA42E6F781E30A0A4A1D721C7
This work was partly supported by a Grant‐in‐Aid for Scientific Research (S) from JSPS (No. 21225004).
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201105636